二仙养骨汤合福善美对绝经后骨质疏松症骨密度及细胞因子的影响  

CLINICAL OBSERVATION ON INFLUENCE OF ERXIANYANGGUTANG AND FOSAMAX ON BONE DENSITY AND CYTOKINE OF POSTMENOPAUSAL OSTEOPOROSIS

作　　者：黄建武[1] 陈金春[2] 黄建华[1] 林爱菊[1] 林小珍[1] 

机构地区：[1]浙江省温州医学院附属第三医院,瑞安325200 [2]浙江省瑞安市人民医院分院

出　　处：《中医正骨》2008年第3期12-13,15,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：浙江省中医药管理局科技项目2007CB203

摘　　要：目的:观察二仙养骨汤合福善美对治疗绝经后骨质疏松症的骨密度(BMD)和细胞因子的影响。方法:将67例绝经后骨质疏松症患者随机分为治疗组(34例)用二仙汤合福善美和对照组(33例)用福善美,均经6个月治疗,观察两组治疗前后骨密度T值及细胞因子水平,并进行统计学分析。结果:治疗组治疗前后骨密度T值和血清IL-1、IL-6、TNF-α改善明显(P<0.05);对照组治疗前后的骨密度T值改善明显(P<0.05),血清IL-1、IL-6、TNF-α改善不明显(P>0.05)。两组间比较,各项指标差异均有统计学意义(P<0.05)。结论:二仙养骨汤合福善美治疗绝经后骨质疏松症能显著降低患者的细胞因子水平,提升骨密度值,是防治绝经后骨质疏松症的有效方法。Objective:To observe the influence of ERXIANYANGGUTANG(EXYGT,a TCM composition) and Fosamax on bone density and cy-tokine of postmenopausal osteoporosis.Methods:158 cases of patients with postmenopausal osteoporosis,were randomly divided into two groups,therapy group(34 cases,cured with EXYGT and Fosamax) and control group(87 cases,with Fosamax).They were treated for six months.T values of bone density and levels of cytokine were observed prior and post-treatment,and they were analyzed statistically.Results:Of therapy group,there had significant deviation on T values of bone density and IL-1,IL-6,TNF-αin blood-serum(P < 0.05),and so in two groups.In control group significant deviation was seen on T values of bone density prior and post-treatment(P < 0.05),but not on IL-1,IL-6,TNF-α in blood-serum(P > 0.05).Conclusion:The method above was valid for curing postmenopausal osteoporosis for it s degrading levels of cytokine obviously and upgrading values of bone density.

关 键 词：绝经后骨质疏松症/治疗 二仙养骨汤/药效学 福善美 骨密度 细胞因子 临床研究 

分 类 号：R580[医药卫生—内分泌]