色谱指纹图谱在中药质量控制中的应用  

Quality control of Chinese herbal medicines with chromatographic fingerprints

作　　者：周建良[1] 齐炼文[1] 李萍[1] 

机构地区：[1]中国药科大学生药学教研室现代中药教育部重点实验室,江苏南京210009

出　　处：《色谱》2008年第2期153-159,共7页Chinese Journal of Chromatography

基　　金：国家杰出青年科学基金资助项目(No.30325046)

摘　　要：介绍了色谱指纹图谱在中药质量控制体系,即中药真实性鉴定(化学指纹图谱)、有效性评价(谱效学、生物指纹图谱、代谢指纹图谱)以及安全性评价方面的应用。目前化学指纹图谱在中药的真实性鉴定方面已比较成熟;谱效学、生物指纹图谱和代谢指纹图谱由于与药效活性相关,在中药的有效性评价中已体现出优势;色谱指纹图谱在中药的安全性评价方面的应用也愈来愈受到重视。The applications of chromatographic fingerprint in the quality control of Chinese herbal medicines（CHMs）,such as chemical fingerprint in the authentication of CHMs,chromatographic pharmacodynamics,biofingerprint and metabolic fingerprint in the efficacy evaluation of CHMs are reviewed.In recent quality control system of CHMs,chemical fingerprint has been a forceful technology in the authentication of CHMs,and chromatographic pharmacodynamics,biofingerprint and metabolic fingerprint have shown advantages in the efficacy evaluation of CHMs because of their correlations with pharmacological activities.Furthermore,the application of chromatographic fingerprint in safety evaluation of CHMs becomes more and more significant.

关 键 词：色谱指纹图谱 谱效学 生物指纹图谱 代谢指纹图谱 真实性鉴定 有效性评价 安全性评价 中药 

分 类 号：O658[理学—分析化学]