儿茶酚胺激动剂和阻断剂对大鼠胃粘膜适应性细胞保护作用的影响  

EFFECT OF CATECHOLAMINERGIC AGONISTS AND ANTAGONISTS ON ADAPTIVE GASTRIC MUCOSAL PROTECTION IN RATS

作　　者：李蕾[1] 刘建中[1] 赵文[1] 许继田[1] 姚运纬[1] 伍忍[1] 

机构地区：[1]河南医科大学生理教研室

出　　处：《中国应用生理学杂志》1997年第2期174-176,共3页Chinese Journal of Applied Physiology

基　　金：河南省卫生厅重点资助

摘　　要：本文观察了儿茶酚胺激动剂和阻断剂对大鼠慢性应激诱发的胃粘膜适应性细胞保护作用的影响，并分析内源性生长抑素与保护作用的关系。结果表明，慢性应激诱导的大鼠胃粘膜适应性保护作用在交感神经切除后完全消失，多巴胺或异丙肾上腺素使保护作用部分恢复，去甲肾上腺素无作用；在交感神经完整大鼠，心得安或氟哌啶醇可抑制慢性应激诱发的保护作用，酚妥拉明无作用。血浆生长抑素在应激及交感神经切除后均无显著变化。提示慢性应激时交感肾上腺系统的激活参与了大鼠胃粘膜适应性保护作用，且可能通过多巴胺及肾上腺能β受体介导。The gastric mucosal damage caused by 70% ethanol significantly decreased in rats pretreated with chronic mild restraint stress (CMRS, P<0 001). This adaptive mucosal protection induced by CMRS was absent in sympathectomized rats, while the administration of isoprenaline or dopamine could partially, and norepinephrine could not, restore the protection. In rats with rntact sympathetic nerve, preinjection of haloperidol or propranolol inhibited CMRS induced protection which, however, was not affected by phentolamine. No change in plasma somatostatin level was observed either in stress or sympathectomized rats alone or in stress plus sympathectomized rats. The results suggest that the sympathetic nerve or its mimetic agent ang this is are involved in the adaptive protection of the gastric mucosa possibly mediated through β and dopamine receptors.

关 键 词：胃粘膜 慢性应激 儿茶酚胺 适应性细胞保护 

分 类 号：R333.2[医药卫生—人体生理学]