大气悬浮颗粒物不同有机组分的致突变性研究  

THE MUTAGENICITY OF AIRBORNE PARTICLES AFTER SUBFRACTION

作　　者：赵贤四[1,2] 朱惠刚[1,2] 

机构地区：[1]上海铁道大学医学院预防医学教研室 [2]上海医科大学环境卫生教研室

出　　处：《癌变．畸变．突变》1997年第4期204-208,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文根据城市功能区选择４个点采样，颗粒物提取物分成五个组份，分别测定致突变性。结果发现：ＰＡＨ组份，有机酸组份和极性化合物组份有较强的致突变性；冬季颗粒物致突变性比夏季颗粒物致突变性强；主要引起ＴＡ９８菌株的移码型突变，加入活化系统可不同程度地增加提取物致突变性。表明上海市大气污染已是一个严重的、亟待解决的问题。Four samples were collectted at different functional regions of Shanghai,and were subfractionated according to its polarity into organic acids,organic alkali,PAH,alkane,and polar components.Ames test was used for detecting the mutagenicity of each fractions.The resultes showed that the PAH,organic acids and polar components have strong mutagenic activities.Meanwhile,S9 can increse the activity due to induce indirect mutagens into direct ones.The mutagenic activity of winter samples were stronger than that of summer samples.We should see from this test that control air pollution is one of emergent,serious taskes in Shanghai now.

关 键 词：大气颗粒物 致突变性 环境毒理学 

分 类 号：R994.6[医药卫生—毒理学]