药物体外肝代谢研究方法  

Research of Present Conditions of Liver Metabolism in Vitro of Medicine

作　　者：王佳[1] 代百东[1] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心/国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076

出　　处：《亚太传统医药》2008年第3期48-50,共3页Asia-Pacific Traditional Medicine

摘　　要：对近几年的文献资料进行分析、综合、归纳。介绍肝微粒体体外温孵法、肝细胞体外温孵法、离体肝灌流及器官组织切片法。其中,肝细胞体外温孵法是当今药物体外肝代谢研究的热点,对新药研究与开发及正确指导临床合并用药有着巨大的推动作用,将对其进行重点论述。According to recent materials, Introduce liver microsome incubations in vitro, liver cell incubations in vitro, isolated perfused liver and liver slices, respectively. Among all these methods, liver cell incubation is the hot spot of liver metabolisms in vitro of medicine, and it takes great part in new drug study development and correct directing clinical combine drugs. This overview will take it as a main point.

关 键 词：体外肝代谢 肝微粒体 肝细胞 离体肝灌流 组织切片 

分 类 号：R969[医药卫生—药理学]