二氢青蒿素抑制兔耳瘢痕增生的实验研究  

Effects of dihydroartemisinin on the hypertrophic scar in rabbits ears

作　　者：冯登超[1] 贺光照[1] 江川[1] 张伟[1] 黄崇本[1] 

机构地区：[1]重庆医科大学附属第一医院烧伤整形科

出　　处：《中国美容医学》2008年第3期380-382,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察二氢青蒿素对兔耳增生性瘢痕增生的影响。方法:选取成年新西兰大耳白兔16只,建立兔耳增生性瘢痕动物模型,待上皮化后,对实验组、对照组分别给予二氢青蒿素(180mg/kg)和生理盐水(乙醇终浓度为0.1%)各10ml灌胃,术后28天和56天时观察药物对瘢痕增生指数(HI)的影响及光镜下瘢痕变化情况。结果:二氢青蒿素组与生理盐水组之间HI差异均有显著性意义(P<0.O1);光镜下见二氢青蒿素组成纤维细胞凋亡增加及胶原纤维的含量降低。结论:二氢青蒿素可明显抑制兔耳增生性瘢痕的形成及瘢痕组织增生。Objective To investigate the effects of dihydroartemisinin on the hypertrophic scar through hypertrophic scarring of rabbits ears model. Methods Sixteen New Zealand white rabbits were used to establish the models of hypertrophic scar in ears. The rabbits in the experimental and control groups were received each 10 ml dihydroartemisinin by perfusion in dose of 180g/kg and 0g/kg （normal saline） after epithelization.At day 28 and 56 the rabbits were killed to observe hypertrophic index （HI） and morphological change of scars. Results Compared with the control group, dihydroartemisinin significantly reduced HI （P〈0.01）. The proliferation of fibroblast was obviously inhibited and the contents of collagen fiber were decreased in the dihydroartemisinin treated group under light microscope on postoperative 28th and 56th day. Conclusion Dihydroartemisinin can inhibit formation of hypertrophic scar in rabbit ears.

关 键 词：二氢青蒿素 增生性瘢痕 兔耳瘢痕模型 

分 类 号：R619.9[医药卫生—外科学]