广州地区女性不同人群HSV-2感染调查及危险因素分析  

ANALYSIS OF RISK FACTORS AND INVESTIGATION ON HSV-2 PREVALENCE AMONG DIFFERENT FEMALE POPULATION IN GUANGZHOU

作　　者：汤少开[1] 叶兴东[1] 黄雪梅[1] 曹文苓[1] 邓蕙妍[1] 黎小东[1] 谭学英[1] 丘小珊[1] 

机构地区：[1]广州市皮肤病防治所,广州510095

出　　处：《现代预防医学》2008年第7期1203-1205,共3页Modern Preventive Medicine

基　　金：广州市疾病控制项目;广州市卫生局科研立项(2005-YB-201)

摘　　要：[目的]调查广州地区女性不同人群单纯疱疹病毒-2(HSV-2)感染情况及有关危险因素。[方法]由性病艾滋病高危人群干预工作队成员对流动人口、妇科门诊、性工作者等不同人群中的女性进行现场问卷调查,并采集血液标本,ELISA法检测HSV-2抗体、HIV,RPR/TPPA确诊梅毒,宫颈拭子检测沙眼衣原体,淋球菌等。[结果]调查对象HSV-2抗体总体阳性率为24.5%,流动人口、妇科门诊、性工作者女性HSV-2阳性率分别为14.6%、18.7%、47.5%;HSV-2感染独立危险因素包括有非固定性伴、初次性生活年龄小于20岁以及阴道异常分泌物、每周性生活频率多于3次;年龄26￣34岁为HSV-2感染的保护因素。[结论]广州地区女性人群中,性工作者HSV-2感染率最高,性工作者是性病行为干预的重点。多个性伴、性生活频率越高、初次性生活年龄越早越有可能感染HSV-2。[Objective] In order to investigate the HSV-2 prevalence and associated risk faetors among different female groups in Guangzhou. [ Methods] Professional STD/AID intervention team was organized to provide STD/AIDS prevention service for risk population. Data were collected by interviewers and anonymous forms were filled by different female population on site ＇after health education. Blood samples were collected for HSV-2 antibody, HIV antibody detection by ELISA. Syphilis was diagnosed by RPR/TPPA. Chlamydia trachomatis and gonococcus were detected by cervix swabs. [ Results] The general prevalence rate of HSV-2 was 24.5% among all objects, and 14.6%, 18.7%, 47.5% respectively for fluid population, patients from clinic service of gynecology and commercial sex workers. Independent risk faetors included age of firstly happened sex life lower than 20 years old （OR=0.25, 95%CI=0.14-0.43）, non-fixed sex partner （OR=4.4, 95%CI=3.1-6.2）, abnormal vaginal discharge （0R=2.9, 95%CI=2.0-4.3） and the frequency of sex life more than 3 times per week （OR=l,8, 95%CI=1.2-2.7）. The age of 26-34 years old was a protective factor for infection of HSV-2 （OR=0.3, 95% CI=0.2-0.5）. [Conclusion] The HSV-2 prevalence rate of commercial sex workers is the highest among different female population in Guangzhou, who is one of the most target populations for STD/AIDS behavior intervention. And people who have more sex partners, sex frequencies and earlier first sex life have more opportunities for HSV-2 infection.

关 键 词：单纯疱疹病毒 女性 调查 生殖器疱疹 

分 类 号：R759[医药卫生—皮肤病学与性病学]