大学生接种重组酵母乙肝疫苗后免疫效果临床研究  

CLINICAL RESEARCH ON IMMUNO-RESPONSE OF UNDERGRADUATE STUDENTS TO RECOMBINANT YEAST HBV VACCINE

作　　者：李绍刚[1] 黄忠爱[1] 陈坚兰[1] 戴岚[1] 

机构地区：[1]广西财经学院医院,南宁530003

出　　处：《现代预防医学》2008年第7期1346-1347,共2页Modern Preventive Medicine

摘　　要：[目的]了解大学生接种重组酵母乙肝疫苗后的免疫效果,为乙型肝炎预防提供资料。[方法]以某学院2003年入学HBsAg检测呈阴性的1350名学生为对象,按免疫程序分别接种重组酵母乙肝疫苗5μg/支3针,观察其免疫1、2、3年后血清的抗-HBs阳转率,并对免疫无应答(HBV5项指标全部阴性)的学生,加强疫苗接种(10μg和20μg/支),按免疫程序分别再接种3针重组酵母乙肝疫苗,1个月后再检测抗-HBs阳转率。[结果]全程接种乙肝疫苗1年后检测抗-HBs阳转率为88.51%,2年后为83.79%,3年后为73.77%,与全程免疫后1年相比,差异有统计学意义(P﹤0.05)。加强疫苗接种剂量10μg和20μg分别按程序接种后,1个月抗-HBs阳转率达96%和98%,与加强免疫前比较,差异有统计学意义(P﹤0.05)。[结论]重组酵母乙肝疫苗免疫效果良好,但必要时需加强免疫,增加抗体应答者的远期免疫效果,发挥其免疫保护作用。[ Objective] To investigate the immuno-response of undergraduate students to recombinant yeast HBV vaccine. [Methods] 1 350 undergraduate students whose HBsAg were negative in 2003 were Vaccinated recombinant yeast HBV vaccine at the dosage of 5μg three times. The positive conversion rate of sera anti-HBs was followed up three yearsl Students who had no immune-response to vaccine were re-vaccinated at a higher dosage （ 10μg and 20μg） and the positive conversion rate of sera anti-HBs was followed serum anti-HBs one month later. [ Results] The positive conversion rate of sera anti-HBs was 88.51% one year after vaccination, and 83.79% after two years, 73.77% after there years respectively （P 〈 0.05）. Enhanced vaccination resulted in 96% and 98% positive conversion rate of sera anti-HBs in one month （P 〈 0.05）. [Conclusion ] Recombinant yeast HBV vaccine is effective in inducing immuno-response, but enhanced vaccination might be necessary to guarantee the long-term protection.

关 键 词：重组酵母乙肝疫苗 免疫效果 大学生 

分 类 号：R186[医药卫生—流行病学]