硝苯地平治疗慢阻肺疾病的近期疗效研究  

RESEARCH ON SHORT-TERM CURATIVE EFFECT OF NIFEDIPINE ON THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：樊新生[1] 樊飒娟[1] 唐年秀[1] 刘航涛[1] 

机构地区：[1]湖南环境生物职业技术学院医学系,衡阳421001

出　　处：《现代预防医学》2008年第7期1368-1369,共2页Modern Preventive Medicine

基　　金：湖南省卫生厅科研基金资助(B2007199)

摘　　要：[目的]观察硝苯地平对慢性阻塞性肺病(COPD)的近期疗效。[方法]用临床对比分析法的设计方法,观察硝苯地平对COPD患者[一秒钟用力呼气容积(FEV1)/用力肺活量(FVC)﹤70%]的近期疗效。在70例患者中,治疗组36例(硝苯地平10～20mg,每日3次),对照组34例(常规综合治疗)。[结果]两组均衡性检验有可比性;应答率比较:治疗组总有效率94.5%,对照组82.3%,治疗组明显高于对照组,两组差异有统计学意义(P﹤0.05);FEV1和动脉血二氧化碳分压(PaCO2)恶化不明显(P﹥0.05)。[结论]本文结果显示硝苯地平用于阻塞性肺病(COPD)的辅助治疗,获显著疗效。[ Objective] To observe the short-term curative effect of nifedipine on the treatment of chronic obstructive pulmonary tuberculosis （COPD）. [Methods] Used clinical contrastive analysis method, observed the short-term curative effect of nifedipine on treatment of COPD patients [forced expiratory volume per second （FEV1）/forced vital capacity （FVC） 〈 70%]. There were 70 patients, treatment group 36 cases used nifedipine 10-20rag ter die, control group 34 cases used routine and combined therapy. [ Results] Balanced examinations in two groups had the comparability. Compared the response rates： total effective rate was in the treatment group was 94.5%, which in the control group 82.3%. The total effective rates was obviously higher in the treatment group than that in the control group, the difference was significant （P 〈 0.05） ： the aggravations of FEV1 and arterial partial pressure of carbon dioxide （PaCO2） were not obvious （P 〉 0.05）. [Conclusion] The results show that the effects of nifedipine on the adjunctive treatment of COPD are remarkable.

关 键 词：硝苯地平 阻塞性肺病 近期疗效 

分 类 号：R56[医药卫生—呼吸系统]