羟基磷灰石负载锰催化溴苯的Suzuki反应  

Suzuki Reactions of Aryl Bromides Catalyzed by Hydroxyapatite-Supported Manganese

作　　者：乔江彬[1] 朱雯芳[1] 卓广澜[1] 周浩[2] 姜玄珍[2] 

机构地区：[1]浙江理工大学化学系,浙江杭州310018 [2]浙江大学化学系,浙江杭州310014

出　　处：《催化学报》2008年第3期209-211,共3页

基　　金：国家自然科学基金(20476092)

摘　　要：以羟基磷灰石（HAP）负载Mn作为催化剂（MnHAP）催化溴苯与苯硼酸的Suzuki交叉偶联反应.以氟离子交换羟基磷灰石的羟基（MnFAP）后,催化剂的活性显著提高,在优化的反应条件下能得到约70%的产率.进一步考察了溶剂和不同取代基的影响.结果表明,MnFAP作用下溶剂极性对反应有很大影响,当溶剂DMF/H2O比例为1/3时产率最高.对于不同取代基取代的溴代芳烃或苯硼酸,可以得到中等产率（18%~46%）的偶联产物.Suzuki cross-coupling reactions between aryl bromides and phenylboronic acids were studied over a hydroxyapatite-supported Mn catalyst （MnHAP） for the first time. An increased yield was obtained over the fluoride ion-exchanged hydroxyapatite-supported Mn catalyst （MnFAP）, Under optimized conditions, the yield was about 70 %. The effect of solvent compositions and different substituents were studied over the MnFAP catalyst. The DMF-H2O mixture with a DMF/H2O volume ratio of 1/3 was the best solvent. Moderate yields （18%- 46 % ） were obtained for all tested aryl bromides and phenylboronic acids substituted by different groups.

关 键 词：SUZUKI反应 羟基磷灰石 氟交换 锰 溴代芳烃 苯硼酸 

分 类 号：O643.32[理学—物理化学]