高效液相色谱方法分离3,4-二甲基苯甲醛和2,3-二甲基苯甲醛  

Separation and Determination of 2,3-Dimethylbenzaldehyde in 3,4-Dimethylbenzaldehyde by High Performance Liquid Chromatography

作　　者：程玉国 李玉红[2] 阎圣刚[2] 蒋山[2] 李刚月[2] 

机构地区：[1]常熟市虞西化工有限公司,江苏常熟215557 [2]大连海事大学高分子材料研究所,辽宁大连116026

出　　处：《广东化工》2008年第3期78-80,共3页Guangdong Chemical Industry

摘　　要：通过邻二甲苯与甲醛反应合成了3,4-二甲基氯化苄,用Sommelet反应合成了3,4-二甲基苯甲醛。利用液相色谱方法分析了3,4-二甲基苯甲醛合成过程中的异构体2,3-二甲基苯甲醛。色谱柱为C18柱(150 mm×4.6 mm,φ5λm),流动相为甲醇和水,柱温为30℃,流速为1.2 mL/min,线性梯度洗脱,紫外检测波长为280 nm。在此条件下,异构体2,3-二甲基苯甲醛与3,4-二甲基苯甲醛可以较好地分离。3,4-dimethylbenzylchloride was prepared by the reaction of o-xylene with formaldehyde. 3,4-dimethylbenzaldehyde was synthesized by the reaction of Sommelet using the 3,4-dimethylbenzylchloride. The isomer of 2,3-dimethylbezaldehyde in 3,4-dimethylbeza-ldehyde was separated by high performance liquid chromatography （HPLC） on a C18 column （150mm×4.6mm,φ5λm）. The mobile phase of methanol/water, flow rate of 1.2 mL/min, column temperature of 30 ℃ and 265 nm wavelength of detector were used. The compositions were separated completely under this chromatography conditions.

关 键 词：3 4-二甲基苯甲醛 2 3-二甲基苯甲醛 液相色谱 

分 类 号：TQ028.8[化学工程] O625.41[理学—有机化学]