替普瑞酮对幽门螺杆菌和氨基己糖作用的临床研究  

EFFECTS OF TEPRENONE ON H.PYLORI AND HEXOSAMINE:A CLINICAL STUDY

作　　者：董秀云[1] 叶嗣懋[1] 林三仁[1] 陈寿坡[2] 刘新光[3] 贾博琦[3] 

机构地区：[1]北京医科大学第三医院消化科,100083 [2]北京协和医科大学 [3]北京医科大学第一医院

出　　处：《北京医科大学学报》1997年第5期443-445,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：观察胃粘膜保护剂替普瑞酮、麦滋林对胃粘膜幽门螺杆菌（Hp）感染和粘膜防御能力的作用。方法：用比色的方法测胃粘膜氨基已糖含量，用W－S银染色法检查Hp，观察1993年～1994年中收治的慢性浅表性胃炎患者。结果：替普瑞酮增加Hp阴性（18±5）mg／g和阳性（16±4）mg／g病人的胃粘膜氨基已糖含量；安滋林组治疗前后氨基已糖无明显增加。替普瑞酮、麦滋林抑制Hp，有效抑制率分别为76．92％和77．78％，两者无显著差异（P＜0．05）。结论：替普瑞酮和安滋林抑制Hp的生长，这种抑制作用似乎和氨基已糖的增加关系不十分密切。Objective: To observe the effects of Teprenone and Marzulene-s on H. Pyori infection and the gastric mucosal contents of Hexasamine (Hex). Methods: H. Pylori was examined by W-S stain before and after treatment. Determination of Hex was performed by colorimetry. The study included patients with endoscopically proven gastritis. Results: 1. The Hex level was increased by Trprenone in H. Pylori negative and positive groups. 2. H. pylori was inhibited in Teprenone and Marzulene-s groups. The inhibiting ratio was 76. 92 % and 77. 78 % respectively. But there was no significant difference between these two groups.Conclusion: H. Pylori was inhibited by Teprenone and Marzulene-s. The effect may not correlated to the Hex.

关 键 词：替普瑞酮 幽门螺杆菌 氨基己糖 胃粘膜 药物疗法 

分 类 号：R975[医药卫生—药品] R573.105[医药卫生—药学]