Synthesis of Biodegradable Block Copolymer Acyl-Imine with Catalyst of Zinc Powder  

作　　者：ZHONG Min BAI Yu LI Wei LIU Xiaoxuan QU Fanqi 

机构地区：[1]College of Chemistry and Molecular Sciences, WuhanUniversity, Wuhan 430072, Hubei, China [2]College of Xinyang Profession Technology, Xinyang464000, Henan, China

出　　处：《Wuhan University Journal of Natural Sciences》2008年第2期217-220,共4页武汉大学学报（自然科学英文版）

基　　金：the National Key Basic Research Program of China (973 Program) (G2003CB114403)

摘　　要：This paper reported about a polymer of acyl imine synthesized by 3-morpholinone（M） and e-caprolactone（CL） with zinc powder as catalyst. The influence of reaction temperature, reaction time and monomer ratio on the copolymerization reaction was studied. Investigation of monomer reaction ratio and differential scanning calorimeter （DSC） indicated that the copolymer poly（3-morpholinone-e-caprolactone） was a block copolymer, solubility in water, degradation characteristics in vitro and controlled release of 5-FU was also studied. The results showed the hydrophilicity of the copolymer increased with the increasing of M content in the copolymer. With the enhancement of hydrophilicity its degradation rate and drug releasing rate increased as well.This paper reported about a polymer of acyl imine synthesized by 3-morpholinone（M） and e-caprolactone（CL） with zinc powder as catalyst. The influence of reaction temperature, reaction time and monomer ratio on the copolymerization reaction was studied. Investigation of monomer reaction ratio and differential scanning calorimeter （DSC） indicated that the copolymer poly（3-morpholinone-e-caprolactone） was a block copolymer, solubility in water, degradation characteristics in vitro and controlled release of 5-FU was also studied. The results showed the hydrophilicity of the copolymer increased with the increasing of M content in the copolymer. With the enhancement of hydrophilicity its degradation rate and drug releasing rate increased as well.

关 键 词：CATALYST 3-morpholinone Ε-CAPROLACTONE block copolymer degradation controlled release 

分 类 号：Q63[生物学—生物物理学]