有精神病性症状的躁狂发作患者住院治疗对照研究  

A control study on the acute pharmacy therapeutic effects in hospitalized patients with manic episode with psychotic symptoms

作　　者：阳琼[1] 苗国栋[1] 薛士健[1] 徐贵云[1] 温全球[1] 

机构地区：[1]广州市精神病医院,广东广州510370

出　　处：《中国民康医学》2008年第5期383-385,388,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较单一经典抗精神病药物(奋乃静)或心境稳定剂(碳酸锂)合并小剂量经典抗精神病药物(奋乃静)治疗有精神病性症状的躁狂发作的疗效和安全性。方法:将符合入组标准的有精神病性症状的躁狂发作患者79例随机分成两组进行为期6周治疗。一组为单一大剂量奋乃静治疗;另一组为碳酸锂合并小剂量奋乃静治疗。以阳性和阴性症状量表(PANSS)、躁狂量表(Bech-Rafaelsen,BRMS)和临床总体印象量表(CGI)评定患者的疗效,以治疗中需处理的不良反应症状量表(TESS)评定患者的不良反应。结果:在治疗第6周末,单用奋乃静组患者的临床治愈率38.2%,有效率94.1%(33/34),碳酸锂合并小剂量奋乃静组的临床治愈率63.9%,有效率100%(36/36),两组在临床疗效和不良反应上比较有显著性差异(P<0.05),碳酸锂合并小剂量奋乃静组疗效优于单一大剂量奋乃静组,且不良反应相对少见。结论:碳酸锂合并小剂量奋乃静治疗有精神病性症状的躁狂发作的临床疗效优于单一大剂量奋乃静治疗且不良反应相对少见。Objective ：To compare the efficacy and safety between high dosage of perphenazine and low dosage of perphenazine combined with lithium in treating hospitalized patients with manic episode with psychotic symptoms. Methods ：79 patients meeting the enrolled criteria were randomly assigned to receive high dosage of perphenazine sole or lithium combined with low dosage of perphena- zine for 6 weeks. The therapeutic efficacy and side effects were evaluated with Positive and Negative Symptoms Rating （ PANSS）, Bench -Rafaelsen Mania Rating （BRMS） , Clinical Global Impression （CGI） and Treatment Emergent Symptom Scale （TESS） separately. Results： After 6 weeks treatment with the assigned regimen, the total scores of BRMS were significantly reduced from baseline in the two groups. The cure rate was 38.2% and 63.9% for the patient groups treated with perphenazine alone and lithium combined with perphenazine, respectively. The responsive rate was 94.1% and 100% for the patient groups treated with sole perphenazine and perphenazine and lithium combined, respectively. The patient group treated with combined medications showed lower scores of side effects. Conclusions ： Mood stabilizer combined with typical antipsychotics showed a better efficacy and tolerability than traditional antipsychotics alone in treating in -patients with manic episode with psychotic symptoms.

关 键 词：躁狂发作 心境稳定剂 抗精神病药物 

分 类 号：A749.41[哲学宗教—马克思主义哲学]