中国人血中脂类指标的随龄变化  

Changes of Blood Lipids and Lipoprotein Variables with the Change of Age

作　　者：王拥军[1] 袭淑琴[1] 温玫[1] 耿永辉 高蔚然 董秀敏[1] 周茗[1] 

机构地区：[1]首都医科大学宣武医院,北京100053

出　　处：《中国老年学杂志》1997年第5期271-273,共3页Chinese Journal of Gerontology

基　　金：北京市科委科技新星计划资助;北京市优秀青年知识分子基金

摘　　要：选择513例健康人作为研究对象，根据年龄分为9组，测定其血中脂类指标．结果发现血中胆固醇（CH）、甘油三酯（TG）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）在出生时含量较低，以后随增龄而升高；高密度脂蛋白（HDL）在出生时较低，以后逐渐升高．到20岁之前达高峰，以后又逐渐下降，脂蛋白（a）[Lp（a）]自出生后在一生中变化不大，无明显波动；氧化型低密度脂蛋白（ox－LDL）在出生时极低，以后随增龄而升高，到70岁之前达高峰，70岁之后又有下降的趋势．相关分析也发现血CH、TG、LDL、和xo－LDL与年龄之间里明显的正相关，HDL与年纷呈负相关关系，Lp（a）与年龄之间无相关关系．以上结果提示，随着增龄，脂类代谢的变化为动脉粥样梗化的发生提供了更多的物质基础．Five hundred and thirteen healthy subjects were divided into 9 groups according to their ages. Choles-terol, triglyceride, high density lipoprotein (HDL ), low density lipoprotein (LDL), very low density lipopro-tein (VLDL),lipoprotein(a) [Lp (a)] and oxidized low density lipoprotein (ox-LDL) levels of these subjectswere determined. The results revealed that cholesterol,triglyceride,LDL,HDL and VLDL were very low atbirth,and increased as coming of age. It reached the peak be fore 20 years old,and decreased afterwards. Lp(a) did not vary in one's life. Plasma ox-LDL was very low at birth.and increased along with their age. Itreached the peak in seventies and decreased afterwards. The age is positivel correlated with serum choles-terol,triglyceride,LDL and VLDL,inversely correlated with HDL,and Lp(a). It is indicated that as the in-creasing of age the changes of plasma lipid and lipoproteins is prone to atherosclerosis.

关 键 词：血脂 脂类 脂蛋白 中国人 年龄变化 老年人 

分 类 号：R592[医药卫生—老年医学] Q592.1[医药卫生—内科学]