自然杀伤细胞受体及其配体表达的转录和表观遗传调控  

Transcriptional Regulation and Epigenetic Control of Expression of Natural Killer Cell Receptors and Their Ligands

作　　者：周志侠[1] 张彩[1] 

机构地区：[1]山东省医学科学院基础医学研究所,济南250062

出　　处：《生物化学与生物物理进展》2008年第3期255-260,共6页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划项目(973)(2007CB815800);国家自然科学基金资助项目(90713033,30371302,30471572);中国博士后科学基金资助项目(20060390309);山东省博士后科研项目择优资助项目(200603071)~~

摘　　要：自然杀伤(natural killercell,NK)细胞受体及其配体在NK细胞发挥抗病毒、抗肿瘤和免疫调节作用中起重要作用.NK细胞功能的发挥取决于NK细胞受体及其配体的表达水平和其所传递信号的综合.病毒、肿瘤和热休克等刺激可以通过激活相应的转录调节因子,提高启动子活性而上调NKG2家族受体及其配体的表达,而启动子区DNA的甲基化状态、组蛋白的乙酰化和甲基化等表观遗传调控,在NK细胞受体及其配体的表达方面亦起重要作用,并决定NK细胞受体的克隆性分布.深入探讨NK细胞受体及其配体的表达调控机制,将为提高NK细胞抗肿瘤和抗感染疗效提供新的策略.Natural killer （NK） cells play an important role in the immune response to viral infection and tumors. The ability of NK cells depends on the integrated signals across the array of stimulatory and inhibitory receptors engaged upon interaction with target cell surface ligands. Some stimulators, including viruses, tumor cells and hot shock, could promote the expression of NKG2 receptors and their ligands via activating certain transcription factors which are capable of up-regulating NKG2 promoters＇ activity. Meanwhile, epigenetic mechanisms including DNA methylation and histone posttranslational modifications are also critical to expression of NKG2 receptors and their ligands and may control the clonally distribution of some NK cell receptors. Investigating the epigenetic mechanisms of NK cell receptors and their ligands might helpful to the rational design of therapy against infection, inflammation, cancer or autoimmune diseases.

关 键 词：自然杀伤细胞 启动子 转录因子 表观遗传调控 甲基化 组蛋白 

分 类 号：R392.2[医药卫生—免疫学] Q78[医药卫生—基础医学]