Preparation and characterization of PEG-PEI/Fe_3O_4 nano-magnetic fluid by co-precipitation method  

作　　者：彭健 邹芬 刘路 唐亮 余丽 陈伟 刘辉 唐静波 邬力祥 

机构地区：[1]National Key Laboratory of Nanobiological Technology,Xiangya Hospital,Central South University [2]Department of Biology,School of Basic Medical Science,Central South University

出　　处：《中国有色金属学会会刊：英文版》2008年第2期393-398,共6页Transactions of Nonferrous Metals Society of China

基　　金：Project(20060390884)supported by the Postdoctoral Science Foundation of China;Project(2006FJ4240)supported by the PostdoctoralScience Foundation of Hunan Province,China;Project(30672047)supported by the National Natural Science Foundation of China

摘　　要：PEG-PEI/Fe3O4 nano-magnetic fluids with different mass fractions of reactant were prepared by co-precipitation method. Besides particle size analyzer,the methods of XRD,IR,VSM and AFM were adopted to characterize the synthesized samples. Covalent bonding of PEG,PEI and Fe3O4 exhibits superparamagnetism.The TEM photograph shows that the particles are of stable dispersion and little aggregation,with smooth surface,spherical shape and a diameter of about 80 nm,which meets the requirements of nano-materials.When the mass fraction of PEI in reactant is 25%,the particle size,Zeta-potential and pEGFP-C1 DNA loading efficiency are all satisfactory.In this case,PEG-PEI/Fe3O4 nano-magnetic fluids can be used as gene vectors or targeted drug carriers.PEG-PEI/Fe3O4 nano-magnetic fluids with different mass fractions of reactant were prepared by co-precipitation method. Besides particle size analyzer, the methods of XRD, IR, VSM and AFM were adopted to characterize the synthesized samples. Covalent bonding of PEG, PEI and Fe3O4 exhibits superparamagnetism. The TEM photograph shows that the particles are of stable dispersion and little aggregation, with smooth surface, spherical shape and a diameter of about 80 nm, which meets the requirements of nano-materials. When the mass fraction of PEI in reactant is 25%, the particle size, Zeta-potential and pEGFP-CI DNA loading efficiency are all satisfactory. In this case, PEG-PEI/Fe3O4 nano-magnetic fluids can be used as gene vectors or targeted drug carriers.

关 键 词：氧化铁 纳米磁性流体 纳米材料 合金 

分 类 号：TB381[一般工业技术—材料科学与工程]