新型β-环糊精衍生物在高效毛细管电泳分离扁桃酸中的应用  

Application of New β-Cyclodextrin Derivative for Separation of Mandelic Acid by High Performance Capillary Electrophoresis

作　　者：雷双双[1] 杨曦[1] 沈静茹[1] 陆俭洁[1] 

机构地区：[1]中南民族大学化学与材料科学学院国家民委分析化学重点实验室,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2008年第1期30-33,共4页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：湖北省自然科学基金资助项目(95J60)

摘　　要：用β-环糊精、马来酸酐、间羧基苯磺酰氯合成了双-[6-氧-(3-间羧基苯磺酰基-丁二酸单酯-4)]-β-环糊精,并对合成的产物进行初步表征.以此β-环糊精衍生物作为手性添加剂用于毛细管电泳中分离扁桃酸,并与纯β-环糊精作为手性添加剂对比,结果表明:新合成的β-环糊精衍生物的拆分能力明显优于天然的纯β-环糊精.A new derivative of bis-[6-Oxygen-（3-m - carboxylbenzene sulfonyl-butane diacid - monoester-4）-]-β- CD was synthesized using β-cyclodextrin, maleic anhydride and 3-carboxylbenzene sulfonyl chloride. The structure of the derivative was preliminarily characterized. The new derivative was used as chiral selector to separate mandelic acid by high performance capillary electrophoresis. It is found that the chiral separation ability of the new derivative is much better than pure β-cyclodextrin. Keywords β-cyclodextrin derivative; synthesize; chiral selector ; mandelic acid

关 键 词：Β-环糊精衍生物 合成 手性添加剂 扁桃酸 

分 类 号：O657.8[理学—分析化学]