妊娠糖尿病患者脂联素与胰岛素抵抗相关性的初步探讨  

The correlation of adiponectin level with insulin resistance in patients with gestational diabetes mellitus

作　　者：于健[1] 林枫[1] 周素娴[1] 王炎[2] 石青峰[3] 周燕[1] 苏珂[1] 龙艳[1] 刘登岩 

机构地区：[1]桂林医学院附属医院内分泌科,541001 [2]中国人民解放军第181医院妇幼保健中心 [3]桂林医学院附属医院检验科,541001 [4]广西龙胜县人民医院

出　　处：《中国糖尿病杂志》2008年第3期137-138,共2页Chinese Journal of Diabetes

基　　金：广西壮族自治区卫生厅科研课题资助项目(Z2005165)

摘　　要：目的探讨妊娠糖尿病(GDM)患者脂联素与胰岛素抵抗(IR)的关系。方法检测40例GDM患者(GDM)、34例糖耐量正常(NGT)的孕妇作对照(NC)组的血清脂联素水平,同时以稳态模型HOMA-IR计算胰岛素抵抗指数。结果(1)GDM组脂联素水平、HOMA-IR分别为7·83±1·57μg/L,3·57±1·27,对照组分别为9·36±1·41μg/L、2·98±1·03,两组比较差异有统计学意义。(2)GDM组多元线性逐步回归分析结果显示孕前BMI、脂联素是影响GDM患者IR的独立危险因素。结论GDM患者血清脂联素减少与IR密切相关。Objective To investigate the correlation of adiponectin level with insulin resistance in patients with gestational diabetes mellitus（GDM）. Methods Adiponectin was determined in 40 patients with GDM and 34 control subjects. The insulin resistance index （HOMA-IR） was calculated. Results （1） The meams of adiponectin and HOMA -IR were （7.83 ±1.57 ）μg/L and （3.57 ±1.27 ）respectively in GDM group and （9. 36±1.41）μg/L and（2. 98±1.03） respectively in the control subjects（all P〈0.05）. （2） A multiple linear stepwise regression analysis indicated that BMI and adiponectin were independent factors affecting HOMA-IR. Conclusions Adiponectin level is lower in GDM compared with control subjects,and adiponectin might play an important role in pathogenesis of insulin resistance.

关 键 词：妊娠糖尿病 脂联素 胰岛素抵抗 

分 类 号：R714.2[医药卫生—妇产科学]