空腹血糖水平与胰岛β细胞功能关系的研究  

Study of the relationship between fasting blood glucose and islet β cell function

作　　者：范爱红[1] 陈燕[1] 叶山东[1] 徐卓华[1] 

机构地区：[1]安徽医科大学附属省立医院,安徽省立医院内分泌实验室,合肥230001

出　　处：《中国糖尿病杂志》2008年第3期150-151,共2页Chinese Journal of Diabetes

基　　金：安徽省卫生厅科研基金资助项目(2002B030)

摘　　要：411例入选者均行OGTT或馒头餐-胰岛素释放试验,并测定空腹胰岛素原。根据FPG水平分为7组。结果显示随FPG升高,HOMA-β功能指数和糖负荷30分钟后净增Ins与净增萄萄糖比值逐渐降低;空腹胰岛素原和空腹胰岛素原/FIns数值逐渐升高;FPG≥8mmol/L,胰岛素曲线下面积逐渐降低。FPG结合FIns测定是反映胰岛β细胞功能的一种简单而实用的方法,对临床处理有指导价值。411 subjects were divided into six groups according to their FPG levels. And OGTT was carried out. Result showed that along with the FPG increasing, HOMA β-cell index and △I30/AG30 were decreased progressively, and the fasting serum proinsulin level and ratio of proinsulin/insulin were increased markedly. The area under insulin curve decreased gradually when FPG was above 8 mmol/L. In conclusion, FPG is a reflection of islet β cell function.

关 键 词：胰岛Β细胞功能 空腹血糖 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]