超敏C反应蛋白、脂蛋白(α)和脂联素集成检测诊断冠心病的价值  

Value of integrated detection of serum high-sensitivity C-reactive protein,lipoprotein(α) and adiponectin in diagnosis of coronary heart disease

作　　者：李健洪[1] 刘映峰[1] 缪绯[1] 金维荣 何笑恬 

机构地区：[1]广州市南方医科大学珠江医院心血管内科,广东广州510280 [2]上海生物芯片有限公司,上海201203

出　　处：《心脏杂志》2008年第2期210-212,共3页Chinese Heart Journal

基　　金：广东省科技计划项目(2007B03150810)

摘　　要：目的探讨超敏C反应蛋白(hs-CRP)、脂蛋白(α)[Lp(α)]和脂联素联合检测对冠心病的诊断价值。方法对161例疑诊冠心病的患者进行冠状动脉造影检查,根据造影结果分为冠心病组和非冠心病组,收集5 ml无抗凝全血标本,分离血清,利用悬浮芯片同时检测同一标本hs-CRP、Lp(α)和脂联素3个指标。结果冠心病组hs-CRP、Lp(α)测定值均显著高于非冠心病组(P<0.01),而冠心病组脂联素测定值显著低于非冠心病组(P<0.01);3个指标集成检测进行平行试验分析时灵敏度(90%)显著高于单个标志物检测的灵敏度[hs-CRP 65%、Lp(α)74%、脂联素58%,P<0.01],进行系列试验分析时特异度(92%)显著高于单个标志物检测的特异度(hs-CRP85%、Lp(α)69%、脂联素75%,P<0.01)。结论集成检测hs-CRP、Lp(α)和脂联素能更准确诊断冠心病,有效的减少漏诊与误诊。AIM To study the value of integrated detection of serum high-sensitivity C-reactive protein （hs-CRP）, lipoprotein（α） [ Lp（α） ] and adiponectin in diagnosis of cαonary heart disease （CHD）. METHODS One hundred and sixty-one suspected cases of CHD underwent cαonary angiography and were classified into CHD group and non-CHD group. 5mL peripheral blood were drawn from all the sub- jects and the serum samples were separated, hs-CRP, Lp（ct） and adiponectin were evaluated and ana- lyzed in both groups by suspension chip. RESULTS The concentration of hs-CRP and Lp（a） was sig- nificantly higher in CHD patients than that in non-CHD subjects （P 〈 0.01 ） and the concentration of adiponectin was significantly lower in CHD patients compared with that in non-CHD subjects （P 〈 0.01 ）. By parallel tests, the sensitivity of integrated detection all the three markers （0.90） was higher than that of single marker detection of either hs-CRP （0.65） α Lp（ct） （0.74） α adiponectin （0.58） （P 〈 0.01 ）. By serial tests, the specificity of integrated detection all the three markers （0.92） was higher than that of single marker detection of either hs-CRP （0.85） α Lp（α） （0.69） α adiponectin （0.75） （ P 〈 0.01 ）. CONCLUSION Integrated detection of three markers of hs-CRP, Lp（α） and adiponectin is mαe accurate and reliable in the diagnosis of CHD.

关 键 词：超敏C反应蛋白 脂蛋白(Α) 脂联素 冠状动脉疾病 悬浮芯片 

分 类 号：R541.4[医药卫生—心血管疾病]