不同类型冠心病患者血清sCD40L水平及其临床意义  

Clinical significance of serum sCD40L changes in patients with different types of coronary heart diseases

作　　者：陈颖敏[1] 徐瑾[1] 李洪波[1] 应小盈[1] 宋玮[1] 丁鸿毅[1] 谢秀兰[1] 王彬尧[1] 何奔[1] 

机构地区：[1]上海交通大学医学院附属仁济医院心内科,上海200001

出　　处：《心脏杂志》2008年第2期213-215,共3页Chinese Heart Journal

摘　　要：目的探讨不同类型冠状动脉粥样硬化性心脏病患者中的血清可溶性CD4OL(sCD40L)水平的变化及其临床意义。方法本研究采用酶联免疫吸附法,对正常对照组25例,稳定型心绞痛(SA)25例,急性冠脉综合征(ACS)50例[其中包括不稳定型心绞痛(UA)29例,急性心肌梗死(AMI)21例]的血清sCD40L水平进行检测。结果①ACS组血清sCD40L水平明显比SA组和对照组高(P<0.01);②AMI组与UA组血清sCD40L水平比较两者无统计学差异;③SA组与对照组相比无统计学差异;④SA发展为UA时sCD40L显著升高。结论sCD40L升高在ACS的发生发展中具有极其重要的作用,sCD40L升高可作为不稳定动脉粥样硬化班块的一个检测指标。AIM To investigate the clinical significance of serum soluble CD40L （sCD40L） changes in patients with different types of coronary heart diseases. METHODS Twenty-five normal subjects made up the control group and 75 patients, including 25 with stable angina pectoris （SA）, 29 with unstable angina pectoris （UA） and 21 with acute myocardial infarct （AMI） were enrolled in this study. The serum sCD40L levels were measured by ELISA. RESULTS ①sCD40L levels were significantly higher in patients with acute coronary syndrome （ACS） ②The serum sCD40L levels in UA patients and AMI patients were higher compared with those with SA and those in control group （P 〈0.01 ）, with no significant difference between AMI and UA and between SA and control group; ③The serum sCD40L was significantly higher when SA deteriorated to UA. CONCLUSION The increasing levels of sCIMOL may play an important role in ACS, which can be used as a potential marker of plaque instability.

关 键 词：血清可溶性CD40L 冠状动脉疾病 生物标志物 

分 类 号：R541.4[医药卫生—心血管疾病]