雷公藤多甙在糖尿病大鼠胰腺移植中的作用研究  

Effect of Tripterygium Wilfordii Hook F on Inducing Immune Tolerance in Pancreas Transplantation of Diabetic Rat

作　　者：杨琴[1] 李军杰[2] 孟令祥[2] 孙静[3] 

机构地区：[1]成都医学院解剖与组织胚胎学教研室,成都610083 [2]四川大学华西医学中心临床医学院,成都610041 [3]成都医学院病理教研室,成都610083

出　　处：《四川解剖学杂志》2008年第1期13-14,26,共3页Sichuan Journal of Anatomy

摘　　要：目的探讨雷公藤多甙(TⅡ)对同种异体大鼠胰腺移植排斥反应的影响。方法本实验应用32只胰腺移植Wistar大鼠,分为两组:对照组,TⅡ组;分别于术后每日监测血糖,ELISA检测术后3、7天血清IL-2浓度,取移植物标本行病理学检查。结果TⅡ组大鼠移植后血糖低于对照组;血清IL-2浓度对照组明显高于TⅡ组;TⅡ组移植胰腺排斥反应较对照组轻。结论雷公藤多甙能诱导一定程度的免疫耐受。Objective To investigate the function of Tripterygium Wilfordii Hook F（TⅡ） on inducing immune tolerance of pancreas allograft in diabetic rats. Methods 32 rats were divided into 2 groups： the control group and TⅡ group, whose daily blood glucose was monitored and the concentration of IL-9, in serum on the 3^rd and 7^th day after transplantation were detected with ELISA, respectively. The pancreas tissues were observed by pathology examination. Results The concentration of the blood glucose and the serum IL-9, in TⅡ group were significantly lower than control group, furthermore, the fibrosis in transplantation group was much more ameliorative than that in control group. Conclusion TⅡ may induce immune tolerance to some extent.

关 键 词：胰腺移植 雷公藤多甙 免疫耐受 

分 类 号：R285.5[医药卫生—中药学]