超敏C反应蛋白在冠心病诊断中的应用价值  

The value of high-sensitivity C-reactive protein in patients with coronary heart disease

作　　者：刘明开[1] 佟凤芝[1] 张永全[1] 刘日旭[1] 于义征[1] 

机构地区：[1]大连大学附属新华医院检验科,116021

出　　处：《国际检验医学杂志》2008年第3期200-202,共3页International Journal of Laboratory Medicine

摘　　要：目的研究不同病情冠心病(CHD)患者血清超敏C反应蛋白(hs-CRP)水平的变化,评价hs-CRP在CHD诊断中的应用价值。方法应用日立7180生化分析仪测定hs-CRP水平;用HP2500彩色超声仪测定颈动脉内-中膜厚度(IMT);统计学分析采用t检验和多因素Logistic回归分析。结果CHD组hs-CRP水平和IMT显著高于对照组,2组结果分别为(5.64±1.83)、(0.89±0.51)mg/L;(1.62±0.35)、(0.83±0.21)mm(P<0.01),而且hs-CRP水平与IMT呈明显正相关(r=0.6278,P<0.01);稳定型心绞痛(SAP)、不稳定型心绞痛(UAP)和急性心肌梗死(AMI)组hs-CRP水平呈递增趋势,并且在AMI组和UAP组的表达明显高于SAP组(P<0.01);hs-CRP作为新的危险因素在CHD的病理过程中发挥着重要的作用。结论hs-CRP是CHD的危险因素之一;hs-CRP在CHD不同分组中呈规律性变化,提示hs-CRP检测对CHD的诊断及预后具有潜在的应用价值。Objective To study the variation of serum high-sensitivity C-reactive protein （hs- CRP） level in patients with the different types of coronary heart disease （CHD）, and to evaluate the value of hs-CRP in the clinical diagnosis of CHD. Methods HITACHI 71g0 automatic biochemitry analyzer was applied to measuring the serum hs-CRP level, and HP2500 type color Doppler ultrasound analyzer applied measuring the intima-media thickness （IMT） of carotid artery for all subjects. The results were analyzed with statistical methods, including t test and multiple factor Logistic regression analysis. Results The serum level of hs-CRP and 1MT were significantly higher in CHD group than those of control group （5.64±1.83 vs 0. 89±0.51 mg/L,P〈0. 01;1. 62±0. 35 vs 0. 83±0.21 mm,P 〈0.01 respectively）, and the serum level of hs-CRP was positively correlative to that of IMT （r=0. 627 8,P〈0.01） ; the serum hs-CRP level was elevated step by step following the stable angina pectoris （SAP）, the unstable angina pectoris （UAP） to the acute myocardial infarction （AMI）, and the serum hs-CRP level was significantly higher in AMI group and UAP group than that of SAP group; the serum hs-CRP might be a new and important risk factor for carotid atherosclerosis during the development of CHD. Conclusion hs-CRP is one of the risk factors for coronary heart disease; the serum hs-CRP level is related with the different types of CHD, which suggests that measurement of hsCRP contributes to diagnosis and prognosis evaluation of CHD.

关 键 词：C反应蛋白质 冠状动脉疾病 临床实验室技术 

分 类 号：R446.112[医药卫生—诊断学] R541.4[医药卫生—临床医学]