促红细胞生成素治疗重度新生儿缺氧缺血性脑病效果观察  

An observation of clinical effect of erythropoietin on hypoxic-ischemic encepholopathy in newborn

作　　者：杨晓雯[1] 殷宪敏[1] 朱立平[1] 梁秀玲[1] 

机构地区：[1]泰山医学院附属医院,山东泰安271000

出　　处：《泰山医学院学报》2007年第10期793-795,共3页Journal of Taishan Medical College

摘　　要：目的观察促红细胞生成素对新生儿缺氧缺血性脑病(HIE)的治疗效果。方法用促红细胞生成素治疗重度HIE 20例,同时设对照组20例,两组均给予三项支持、两项对症治疗。观察治疗前后血清超氧化物歧化酶(SOD)和丙二醛(MDA)的水平、脑CT的改变、NBNA评分及生后1个月至12月龄时精神运动发育商(DQ)以评价疗效。结果观察组治疗后血清SOD和MDA的水平、脑CT、NBNA评分及DQ检测结果均明显优于对照组,各项指标经统计学处理,差别无统计学意义(P<0.05,P<0.01)。结论应用促红细胞生成素治疗重度HIE确有明显疗效。Objective：To observe the clinical effect of erythropoietin on bypoxic-ischemic encepholopathy （HIE） in newborn. Methods： 40 cases with severe HIE were divided into two groups： 20 cases in the observation group treated by erythropoietin, and 20 cases in the control group. SOD, MDA, brain CT, NBNA marks and DQ in 1 - 12 months after birth were used as the index to evaluate. Results： SOD, MDA, brain CT, NBNAmarks and DQ in the observation group were better than those in the control group. There were great diferences bettwen the two groups（ p 〈0.05）. Conclusion： It is very effective to use erythropoietin to treat HIE in the newborn.

关 键 词：脑缺氧 脑缺血 促红细胞生成素 超氧化物歧化酶 丙二醛 

分 类 号：R722.1[医药卫生—儿科]