清开灵注射液对大鼠阳离子化牛血清白蛋白肾炎模型的影响  

Effects of Qingkailing Injection on Nephritis Induced by Cationic Bovine Serum Albumin in Rats

作　　者：李世刚[1] 

机构地区：[1]三峡大学医学院药理学教研室,宜昌443002

出　　处：《实用医学进修杂志》2008年第1期30-33,共4页Journal of Practical Training of Medicine

摘　　要：目的：探讨清开灵注射液对大鼠阳离子化牛血清白蛋白（C-BSA）肾炎的药理作用。方法：采用C-BSA建立肾小球肾炎大鼠模型，治疗用清开灵注射液腹腔注射，标本取大鼠肾脏皮质、全血和尿液，分别做24h尿蛋白定量、血清肌酐测定、肾脏病理形态学观察。结果：模型组24h尿蛋白含量比正常对照组显著增高（P〈0．05），荧光检查证实有免疫复合物沉积；清开灵治疗组24h尿蛋白含量较模型组则明显下降（P〈0．05），荧光检查免疫复合物沉积明显减轻。结论：清开灵注射液能够抑制肾脏的免疫炎症反应，具有良好治疗肾小球肾炎的作用。Objective： To study the effects of qingkailing injection on nephritis induced by cationic bovine serum albumin in rats. Methods： C-BSA induced nephritis model was utilized in rats. The effects of qingkailing injection on this model were investigated. Results： Proteinuria of the qingkailing injection group was alleviated. The pathological damages of the qingkailing injection group were less severe in comparison with the model group. Conclusions： Qingkailing injection exerts a good effect in alleviating glomerular immune inflammation in the treatment of C-BSA induced nephritis.

关 键 词：清开灵注射液 C-BSA 实验性肾小球肾炎 

分 类 号：R285.5[医药卫生—中药学] R285.1[医药卫生—中医学]