系统性红斑狼疮患者类胰岛素生长因子-1及瘦素检测分析  

Detection of insulin-like growth factors-1 and leptin in patients with systemic lupus erythematosus

作　　者：林星[1] 潘爱武[1] 孙伏清[1] 庄国梁[1] 陈勇[1] 吴茂春[1] 陈明诚[1] 

机构地区：[1]福建医科大学福清教学医院,福清350300

出　　处：《中国麻风皮肤病杂志》2008年第3期183-184,共2页China Journal of Leprosy and Skin Diseases

基　　金：福建省福清市科技发展基金资助

摘　　要：目的:检测类胰岛素生长因子-1(IGF-1)与瘦素(LEP)在系统性红斑狼疮(SLE)患者中的水平。方法:用放射免疫分析法同时测定42例SLE病人血清IGF-1、LEP水平,与正常人对照。结果:SLE患者血清IGF-1值为(56.2±42.2)ng/mL,显著高于正常人,且与病情活动指标SLEDAI呈正相关(r=0.52,P<0.05)。LEP与正常人无显著性差异。与病情活动无相关性。结论:IGF-1在SLE的发病中可能起一定作用。测定血清IGF-1有助于SLE发病机制研究。Objective： To measure the serum levels of insulin - like growth factors （IGF- 1 ） and leptin in systemic lupus erythematosus （SLE） and to correlate the relationship to the disease activity. Methods： IGF- 1 and leptin were measured by radioimmunoassay in patients with SLE and healthy subjects. Clinical characteristics and the SLE disease activity index （SLEDAI） score were correlated. Results： The level of IGF- 1 was （56.2 ± 42.2） ng/ mL, which was significantly higher in patients with SLE than in the controls, and was positively correlated to SLE- DAI score. There was no significant difference in the level of lepfin between SLE and the controls, and between disease activity and SLEDAI score. Conclusion： The results suggest that IGF- 1 may be involved in the pathogenesis of SLE.

关 键 词：系统性红斑狼疮 胰岛素样生长因子-1 瘦素 

分 类 号：R593.241[医药卫生—内科学]