运用PET和SPECT技术研究水沟穴作用的相对特异性  

Study on Specification of Shuigou(DU26) with Positron Emission Tomography and Single Photon Emission Computed Tomography

作　　者：黄泳[1] 赖新生[2] 唐纯志[2] 杨君军[2] 唐安戊[3] 曾统军[1] 邹燕齐[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515 [2]广州中医药大学针灸推拿学院,广东广州510407 [3]广东省人民医院核医学科,广东广州510080

出　　处：《成都中医药大学学报》2008年第1期5-8,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划资助项目(No.2006CB504505);国家自然科学基金重大研究计划课题(No.90709027)

摘　　要：目的:运用正电子发射型计算机断层显像(PET)和单光子发射型计算机断层显像(SPECT)技术,以血管性痴呆(VD)患者为研究对象,观察针刺水沟穴对脑部的作用特异性。方法:10例血管性痴呆(VD)患者,随机分为2组,A组治以针对偏瘫的常规针刺,B组加用水沟穴,共完成20次治疗。治疗前后所有患者接受PET和SPECT脑功能成像检查。统计比较常规针刺和加用水沟穴后局部脑区葡萄糖代谢和血流量变化幅度。结果:加用水沟穴后,VD患者患脑丘脑的葡萄糖代谢升高幅度大于常规针刺治疗组(P<0.05);健脑额叶、顶叶、小脑的葡萄糖代谢升高幅度大于常规针刺组(P<0.05);VD患者患脑额叶、小脑的血流量升高幅度大于常规针刺治疗组(P<0.05);健脑额叶、顶叶、颞叶、枕叶、小脑的血流量升高幅度大于常规针刺组(P<0.05)。结论:针刺水沟穴,能够相对特异地作用于VD患者的各脑叶、丘脑和小脑,提高其葡萄糖代谢和血流量。Objective： To study the specification of Shuigou （DU26） to the brain with PET and SPECT. Method. Ten Vascular Dementia （VD） patients were randomLy divided into 2 groups. Patients in group A received the routine acupancture treatment for the hemiplegia （ Acu - points were chosen from threeYang meridians of Hand and Foot）, while patients in group B received the treatment of plus needling in Shuigou （DU26） . All the patients were given 20 times treatment and received PET and SPECT scaus before and after the treatment. The changed extents of glucose metabolism and blood flow in different cerebral regions were compared between the 2 groups. Results： The increased extents of glucose metabolism in thalamus of the affected side of brain and in frontal lobe, parietal lobe and cerebellum in healthy side of brain of VD patients were obviously than those of the patients received routine acupuncture treatment （ P 〈 0.05） ; The increased extents of blood flow in frontal lobe and cerebellum of the affected side of brain and in frontal lobe, parietal lobe, temporal lobe, occipital lobe and cerebellum in healthy side of brain of VD patients were obviously than those of the patients reeeived routine acupuncture treatment （P 〈0.05） . Conclusion： Needling in Shuigou （DU26） can specialty affect the cerebral lobes, thalamus and cerebellum in VD patients and improve regional cerebral glucose metabolism and blood flow.

关 键 词：水沟穴 特异性 PET SPECT 血管性痴呆 

分 类 号：R245.3[医药卫生—针灸推拿学] R543[医药卫生—中医临床基础]