120d尾部悬吊大鼠耳石形态及钙含量的改变  

Changes in Morphology and Calcium Content of Otoconia in Rats after 120 d Tail-Suspension.

作　　者：王锦玲[1,2] 刘顺利[1,2] 张立藩 陈杰[1,2] 

机构地区：[1]第四军医大学西京医院耳鼻喉科 [2]第四军医大学航空生理学教研室

出　　处：《航天医学与医学工程》1997年第4期283-287,共5页Space Medicine & Medical Engineering

摘　　要：为研究用尾部悬吊模拟失重时血液头向转移生理效应，观察１２０ｄ模拟失重大鼠耳石扫描电镜所见及其钙含量的改变。结果表明，尾部悬吊１２０ｄ大鼠椭圆囊及球囊耳石呈圆形或不规则形，表面粗糙不平，有细颗粒状物或小球形物突起或凹凸不平，并见有裂隙。Ｘ射线微区分析显示其耳石钙含量较对照组减少，相差非常显著（Ｐ＜０．０１）。提示，１２０ｄ长期模拟失重时血液头向分布及后肢卸荷状态，可引起大鼠耳石变形及钙含量减少变化。The morphology and calcium content of otoconia in rats after long term (120 d) tail-suspension were studied using scanning electron microscopy (SEM) and X-ray microanalysis, respectively.The results showed that after 120 d simulated weightlessness otoconia were round, irregularly shaped, or with fissures, and there were rough and fine granular or small globular substances on the surface. X-ray microanalysis showed that the calcium content in the otoconia of both utricule and saccule was significantly decreased in the 120 d tail-suspended rats than that in control (P<0.01). These results suggest that a long term(120 d) simulation of the headward distribution of blood volume and hindlimb underloading effect induced by weightlessness may cause the morphological changes and lower calcium content of the otoconia.Finally, the possible mechanism and the physiologic meaning of these findings are discussed.

关 键 词：模拟失重 尾部悬吊 耳石 大鼠 钙含量 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]