新型骨水泥粘接固定骨折的动物实验研究  

Experimental Study of a New Type of Cement on Tibia Plateau Fractures Treatment

作　　者：吴子征[1] 张键[1] 陈统一[1] 刘昌胜[2] 陈中伟[1] 

机构地区：[1]复旦大学附属中山医院骨科,上海200032 [2]华东理工大学生物材料研究所,上海200237

出　　处：《中外医疗》2008年第3期75-77,共3页China & Foreign Medical Treatment

摘　　要：目的应用磷酸镁骨水泥（magncsium phosphate cement，MPC）粘接固定家免胫骨平台骨折，探讨其治疗效果、粘接和降解机理。方法20只家免分为两组，第1组15只，第2组5只，通过开放截骨法建立家免双倜胫骨平台骨折模型。第1组：实验组用MPC骨水泥固定，对照组用“L”形钢板固定。第2组：实验组也同样用MPC骨水泥固定，而对照组作空白对照。通过大体观察、影像学．组织学及电解质检查，探讨MPC骨水泥治疗骨折的效果、对体内电解质的影响、粘接和降解机理。结果6周后实验组都获得稳定的骨折愈合，没有发现骨折错位及延迟愈合，MPC骨水泥逐渐被吸收，对体内电解质无明显影响，其对骨折的治疗和钢板固定组达到同样的治疗效果。而空白对照倜均出现骨折错位、畸形愈合。通过对标本的组织学检查发现其粘接机理为镶嵌固定，并通过溶解而逐步降解。结论MPC骨水泥具有一定的粘接强度，能降解，对体内电解质干扼小，是一种较为理想的骨水泥，可以用于骨折的粘接固定。Objective To investigate the effect of Magnesium Phosphate Cement （MPC） on fixing the fractures of rabbit tibia plateau and the mechanism of agglutination and degradation. Methods 20 Rabbits were divided into two groups one group hadl5, the other had5. The tibia plateau fracture models of all20rabbits on both sides were made. In the first group： the test group was fixed with MPC, and the control group was fixed with “L” shaped plate. In the second group： the test group was fixed with MPC as well, and the control group didn＇t receive any treatment. Then the effect of treatment was investigated by radiography, macrography, micrography, SEM and the changes of electrolyte levels.Results In the test group, the fractures were all unioned normally without delayed union and displacement. MPC was absorbed and degraded gradually and the levels of electrolyte had no significant changes. The effect of MPC on fractures treatment was equal to that of the metal plate but the vacant group was all malunioned. From the micrography and SEM, we found that the mechanism of agglutination was inlaying and the mechanism of degradation was through the dissolution.Conclusion MPC has some ability of agglutination, and has no significant affection on serum electrolyte levels, and is degradable. MPC is a promising biomaterial and might potentially be used for fractures treatment.

关 键 词：MPC骨水泥 粘接胫骨平台 骨折 

分 类 号：R318.08[医药卫生—生物医学工程]