简化的Excel表格程序设计静脉推注给药方案  

The Dosage Regimen Design of Bolus Intravenous Administration Based on Microsoft Excel

作　　者：苏银法[1] 杜乐燕[2] 

机构地区：[1]浙江省温州市第二人民医院药剂科,325000 [2]温州医学院附属第一医院呼吸科,325000

出　　处：《医药导报》2008年第4期471-473,共3页Herald of Medicine

基　　金：温州市科技局资助项目(基金编号:Y2003A075)

摘　　要：目的建立一种简便的静脉推注给药方案。方法采用Excel软件编写简化的Excel表格程序。结果输入药动学参数、给药间隔τ、给药剂量初值或维持量(d)和药后时间(t)后,Excel表格显示任一次给药后的t时刻血药浓度、AUC值;通过对Excel表格的操作,显示第n周期(或稳态)任一次给药后的t时刻血药浓度、AUC值和负荷剂量。Excel规划求解法获得最大给药剂量(dmax)、最低给药剂量(dmin)、有效血药浓度时间(tec)。结论该方法设计简单,使用直观简便,既能为临床用药提供安全有效的剂量,又能对某一用药方案作出评价。Objective To establish a method of dosage regimen design of multiple dosing intravenous administration. Methods Microsoft Excel was used to make a program on the pharmacokinetic parameters to show the dosage regimen. Results After inputting the pharmacokinetic parameters, dosing interval （τ） , preliminary or maintenance dose （d）, and time after drug administration, the Excel spreadsheet displayed plasma concentration at any time, area under curve （AUC）, and loading dose after the administration. The time of the effective plasma concentration （ tec ）, the minimum dose （ dmax） and maximum dose （dm=） were obtained by program solution on Excel. Conclusion This design method can provide a safe and effective dosage for clinical administration and evaluate a dosage regimen.

关 键 词：药动学 给药方案 EXCEL 静脉推注 

分 类 号：R969.1[医药卫生—药理学]