地塞米松磷酸钠与青霉素G注射剂配伍稳定性考察  

Compatible Stability of Dexamethasone Sodium Phosphate and Penicillin G Injection

作　　者：徐仙娥[1] 辛学俊 陈方亮[1] 梁震野 

机构地区：[1]浙江省台州市中心医院药剂科,318000 [2]浙江省台州市第一人民医院药剂科,318020

出　　处：《医药导报》2008年第4期473-476,共4页Herald of Medicine

基　　金：浙江省医学会2007年临床科研基金资助项目(基金编号:2007ZYC55)

摘　　要：目的探讨青霉素G钠和地塞米松磷酸钠注射液(DXM)的配伍稳定性。方法以青霉素G钠320万U和不同剂量DXM在5%葡萄糖(5%GS)及0.9%氯化钠注射液(NS)中配伍,室温6 h内观察外观、测pH值、高效液相色谱法测色谱峰高、紫外分光光度法测吸光度(A值)。结果青霉素G钠和DXM两药配伍液6 h内外观澄明,配伍液pH值随DXM剂量增加而上升,并接近中性;紫外分光光度法测定,6 h内吸收曲线未明显改变,最大吸收波长处A值未明显变化;DXM对青霉素G钠色谱峰未见明显影响,在3 h后有轻度稳定作用;DXM 40μg.mL-1对提高青霉素G钠稳定性最强。结论DXM与青霉素G钠在5%GS或NS中配伍,配伍无禁忌,有轻度稳定作用。Objective To study the compatible stability of penicillin G sodium with dexamethasone sodium phosphate injection. Methods 3.2 ×10^6 unit of penicillin G was combined with serial doses of dexamethasone in 5% glucose injection or 0.9% sodium chloride injection. Within 6 hours after mixing, the peak height was determined by HPLC and the absorption was determined by ultraviolet spectrophotometry under room temperature; the outward appearance was observed and the pH wdue of the mixture was determined. Results The outward appearance of the penicillin G combined with dexamethasone was clear and the pH value of the mixture was ascended with the dose of dexamethasone increased within 6 hours, and approached neutral. Both the absorption curve and the absorption under the maximum wave length were not changed significantly within 6 hours by ultraviolet spectrophotometry. No significant influence on the peak of penicillin G was found by dexamethasone, while the mild stabilization effect was observed 3 hours later by HPLC, especially for 40μg·mL^-1 of dexamethasone [ about 10 mg·（250 mL）^-1 ]. Conclusion There is not incompatibility between penicillin G and dexamethasone in 5% glucose or 0.9% sodium chloride injection, and dexamethasone has the mild effect on the stability of penicillin G.

关 键 词：地塞米松 青霉素G 配伍 稳定性 

分 类 号：R977.11[医药卫生—药品] R978.11[医药卫生—药学]