缬沙坦对中年高血压患者P波离散度的影响及临床意义  

Effects of valsartan on p-wave dispersion in middle-aged patients with essential hypertension

作　　者：彭永权[1] 周锡平[1] 

机构地区：[1]泸州医学院附属医院心内科,四川省646000

出　　处：《中国心血管病研究》2008年第4期284-286,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的比较缬沙坦和非洛地平对中年高血压患者P波离散度的影响。方法将年龄40～60岁的132例中年原发性轻中度(1～2级)高血压患者随机分为实验组(66例)和对照组(66例),分别接受12周的缬沙坦和氨氯地平治疗。治疗期间监测血压,分别于治疗前和治疗12周后检测心电图及超声心动图。结果两组患者在用药前、后比较,血压(P<0.01)和左心室重量指数(P<0.05)均明显下降,下降程度差异无统计学意义;治疗后,两组患者P波离散度和P波最大时限均显著降低,实验组比对照组降低明显。结论缬沙坦和非洛地平均能有效降压、逆转左心室肥厚,降低P波离散度,在同等降压条件下,缬沙坦能进一步降低P波离散度和P波最大时限。Objective To compare the effects of valsartan and felodipine on P-wave dispersion （Pd） af- ter12-week treatment in middle-aged patients with essential hypertension. Methods One hundred and thirty-two middle-aged mild to moderate hypertensive patients with sinus rhythm were randomly assigned to two groups of 66 patients each.The test group and control group took valsatran and felodipine,respectively.Chnical blood pressure was evaluated every day, 12-lead surface electrocardiongrams were taken and left atrial diameter was measured by eehocardio-graphy before and after 12-week drug therapy. Results Compared with the basehne the pest -treatment values of systolic blood pressure（P〈0.01 ）,diastolic blood pressure （P〈0.01）,and left ventricular mass index （P〈0.05）were significantly decreased in both groups and the extents of decrease were similar between two groups. After 12-week treatment, the maximum P-wave duration （Pmax）and pd were significantly decreased in both groups （P〈0.01）,and the decrease was more marked in test group than in control group （P〈0.01 for pmax,P〈0.05 for Pd）. Conclusion Both valsatran and felodipine are effective drugs to reduce blood pressure,reverse left ventricular hypertrophy, and cause similar blood pressure reduction.Valsartan has much greater lowering effect on pmax and Pd values than felodipine.

关 键 词：缬沙坦 非洛地平 高血压 P波高散度 

分 类 号：R544.1[医药卫生—心血管疾病]