以β-环糊精及其衍生物为手性选择剂毛细管电泳拆分几种药物的旋光对映体  

Enantioseparation of Several Pharmaceutical Racemates With High Performance Capillary Electrophoresis Using β-Cyclodextrin and Its Derivatives as the Chiral Selectors

作　　者：李方[1] 张莉萍[1] 靳慧[1] 顾峻岭[1] 傅若农[1] 王小文 

机构地区：[1]北京理工大学化工与材料学院,北京100081 [2]广东汕头金石制药总厂,汕头515041

出　　处：《分析化学》1997年第6期644-647,共4页Chinese Journal of Analytical Chemistry

摘　　要：在毛细管电泳中，采用β－环糊精（β－ＣＤ）及其衍生物为手性选择剂对扑尔敏、异丙嗪、二氧异丙嗪和氧氟沙星对映体进行了分离。优化了分离条件；讨论了环糊精空腔边缘与溶．质分子作用的基团的种类和分离效果的联系，通过计算手性分离的热力学常数比较了不同手性选择剂对扑尔敏对映体的分离能力。最后，讨论了乙腈在手性分离中的作用。Chlorpheniramine, promethazine. dioxopromethazine and ofloxacin racemates were separated with high performance capillary electrophoresis using β-cyclodextrin or its deriva- tives as chiral selectors. The pH of the background electrolyte and the concentration of chiral selectors were optimized. The structure - resolution relationship was discussed using the various performance parameters and thermodynamic parameters of the enantioseparations. The role of the organic modifier in the chiral separation was investigated by comparing the separation factors before and after the addition of the organic solvent.

关 键 词：药物 环糊精 对映体拆分 扑尔敏 毛细管电泳 

分 类 号：O657.803[理学—分析化学] R97[理学—化学]