青蒿素及其衍生物电化学性质的研究 Ⅰ.青蒿素在汞电极上的电化学还原  

Study on the Electrochemical Behaviors of Artemisinin and Its Derivatives I. Reduction of Artemisinin at Hg Electrode

作　　者：陈扬[1] 朱世民[1] 陈洪渊[1] 李英[2] 

机构地区：[1]南京大学化学系配位化学国家重点实验室,南京210093 [2]中国科学院上海药物研究所,上海200031

出　　处：《化学学报》1997年第9期921-925,共5页Acta Chimica Sinica

基　　金：国家自然科学基金;中国科学院长春应用化学研究所电分析化学开放实验室资助项目

摘　　要：青蒿素及其衍生物代表着一类新型抗疟药.青蒿素分子中过氧基与抗疟活性密切相关.本文采用多种电化学方法研究了青蒿素分子中过氧基在Hg电极上的还原,还原电位在0.OV(vs.Ag/AgCl)附近,电极过程为不可逆还原.反应电子数n=2,半波电位E_(1/2)=0.012V,电子转移系数α=0.66,表观标准电极反应速率常数k_s~’=6.34×10^(-6)cm/s,扩散系数D=4.3×10^(-6)cm^2/s反应产物在电极表面具有吸附性.文中提出了可能的电化学反应机理.Artemisinin and its derivatives represent an important new class antimalarial drug. The peroxide moiety of artemisinin is indispensable for its antimalarial activity. By various electroanalytical methods, the reduction of the peroxide - group of artemisinin at Hg electrode was investigated. The irreversible reduction of artemisinin took place at approximately 0.0V(vs. Ag/ AgCl) by a two - electron transfer, half wave potential E1/2 - 0. 012mV, the charge transfercoefficient a =0.66,apparent standard rate constant ks' = 6. 34 × 10 cm/s, diffusion coefficientD = 4.3 × 10-6cm2/s, the reduced product could be adsorbed on electrode surface. The mechanism of reduction was suggested.

关 键 词：青蒿素 电化学 衍生物 还原 抗疟药 QHS 

分 类 号：R978.61[医药卫生—药品] R282.71[医药卫生—药学]