ATP敏感性钾通道与缺血性脑损伤研究进展  

Research Development of ATP-sensitive K^+ Channels and Ischemic Brain Injury

作　　者：李捷萌[1] 陈彦青[1] 刘荣国[1] 

机构地区：[1]福建医科大学省立临床学院麻醉科,福州350001

出　　处：《医学综述》2008年第7期964-966,共3页Medical Recapitulate

基　　金：福建省自然科学基金项目(2006J0083)

摘　　要：缺血性脑损伤的发生机制目前尚未明确,临床缺乏有效的治疗手段。对ATP敏感性钾通道的研究主要集中于各种组织的缺血及预适应或缺血再灌注的细胞保护方面。研究发现,ATP敏感性钾通道在缺血性脑损伤的病理生理过程中具有重要的作用。本文对该通道的分子结构、在神经系统内的分布、调控机制、相关药物的作用机制和药理学原理、以及其在缺血性脑损伤中的作用机制进行详细的介绍。The mechanism of ischemic brain injury has not been elucidated thoroughly now, and there is no effective therapy in clinic. The research about ATP-sensitive K^＋ channels is mainly focused on the cytoprotection of tissue ischemia and preadaptation or tissue ischemia-repcrfusion. Studies showed that ATP-sensitive K^＋ channels play an important role in the pathophysiological proces- ses of ischemic cerebral injury. This article reviews this chaannel about its molecular structure, distribution in the nervous system, regulatory mechanism, mechanism of action and pharmacological principle of related drugs,and its mechanism of action in the ischemic brain injury

关 键 词：ATP敏感钾通道 脑缺血 调节机制 作用机制 

分 类 号：R318.04[医药卫生—生物医学工程]