靶向超声分子成像与“炎症”的现状、面临挑战和对策  

Current Status,Faced Challenge and Strategies of Targeted Ultrasound Molecular Imaging on Inflammation

作　　者：陈少敏[1] 宾建平[1] 

机构地区：[1]南方医科大学南方医院心内科,广州510515

出　　处：《医学综述》2008年第7期1026-1028,共3页Medical Recapitulate

基　　金：国家"863"计划项目(2006AA02Z478)

摘　　要：利用超声微泡表面固有的生物学特性或通过特殊处理将特定配体连接于超声微泡表面可构建成靶向超声微泡,靶向超声微泡经静脉注入后能靶向性聚集并较长时间滞留于靶组织或靶器官中,并通过对比超声产生分子水平成像。实验研究表明,靶向超声分子成像技术可无创性的定量评价靶组织或靶器官的"炎症",该领域近年来的研究进展十分迅速。By virtue of inherent biological characteristics of the surface of ultrasound microbubbles, or connecting specific ligand to the surface of ultrasound microbubbles through special treatment, the targeted ultrasound microbubbles can be targeted constructed. Via intravenous injection, and can stagnate in the target tissue or target organ for longer time,thus,molecular imaging can be produced by contrast-enhanced ultrasound. Experimental studies have showed that targeting ultrasound molecular imaging could evaluate inflammation of the target tissues and organs in quantitative with noninvasive manner. Studies in this field has mpidly evolved in recent years.

关 键 词：微泡 靶向分子成像 对比超声检查 炎症 

分 类 号：R445.1[医药卫生—影像医学与核医学]