避孕药醋炔诺酮肟对果蝇的致畸性和致突变性的研究  

TERATOGENICITY AND MUTAGENICITY OF CONTRACEPTIVE DRUG NORETHISTERONE ACETATE 3 OXIME IN DROSOPHILA MELANOGASTER

作　　者：王瑶[1,2] 计雪文[1,2] 纪贤文 

机构地区：[1]福州总医院全军医学检验中心 [2]第三军医大学遗传学教研室

出　　处：《癌变．畸变．突变》1997年第5期288-292,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：采用果蝇致畸试验，果蝇伴性隐性致死试验和果蝇非整倍体试验对避孕药醋炔诺酮肟进行致畸和致突变性研究。结果表明当醋炔诺酮肟在浓度分别为５ｍｇ／ｍｌ和５０ｍｇ／ｍｌ时，不引起果蝇致畸率和伴性隐性致死率升高。但在５０ｍｇ／ｍｌ浓度时可引起果蝇非整倍体频率上升，并具有统计学意义。Norethisterone acetate 3 oxime is a newual contraceptive drug whose teratogenicity and mutagenicity is unclear.In this Paper,in order to investigate safety of norethisterone acetate 3 oxime,we studied the teratogenicity and mutagenicity of norethisterone acetate 3 oxime using Drosophila melanogaster teratogenicity test,sex linked recessive lethal test and aneuploid test.The results showed that norethisterone acetate 3 oxime didn't induce to increase of teratogenic rate and lethal rate in Drosophila melanogaster at concentration 5mg/ml and 50mg/ml.But aneuploid frequency which norethisterone acetate 3 oxime induced in Drosophila melauogaster at concentration 50mg/ml was 0.105% and had significant diffence(P<0.01) compared with positive control.The reason was unclear.

关 键 词：避孕药 醋炔诺酮肟 毒性 动物实验 致畸性 突变 

分 类 号：R979.21[医药卫生—药品] R961[医药卫生—药学]