静脉用β-七叶皂甙钠局部不良反应防治的临床研究  

Clinical study of treatment of intravenous Escin local adverse reactions

作　　者：肖静蓉[1] 

机构地区：[1]四川省医学科学院.四川省人民医院骨科,四川成都610072

出　　处：《西南国防医药》2008年第2期218-219,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:探讨临床静脉应用β-七叶皂甙钠的不同药物浓度、合并用药对局部皮肤、血管不良反应的影响,为临床应用该药时减少药物不良反应的发生、提高患者依从性提供依据。方法:对248例静脉输入β-七叶皂甙钠出现局部不良反应进行临床分析研究,总结局部并发症的临床特点及防治措施。结果:本组248例中,191例出现了不同程度的局部不良反应。结果表明,随着β-七叶皂甙钠液体药物浓度的增高,局部不良反应发生率越高,各组之间有显著性差异;在与血塞通、丹参等活血化淤类药物及甘露醇合并使用时,局部不良反应的发生率明显增加,与未合并用药组有显著差异;β-七叶皂甙钠液体浓度相同,配制液体量越多,局部不良反应发生率也越高,但统计学上无显著性差异。结论:严格的无菌技术操作,保护性静脉穿刺,合理的给药方法,强调给药剂量、浓度、持续用药时间等,是减少静脉用药后局部不良反应发生,增加临床治疗中用药依从性的关键。Objective,To study the adverse reaction（ADR） of intravenous Escin and combination with other drugs to local skin and blood vessels in order to reduce ADR of Esdn and improve the compliance of the patients, Methods：The clinical data of 248 cases who had received intravenous Escin therapy were collected. The dinical characteristics of the ADR of Esdn and the therapeutic results were analyzed and compared one another, Results. In these 248 cases, 191 cases suffered from different local ADR. the higher the concentration of Esdn was, the higher the incidence of ADR was. Coadministration with other drugs such as Danshen injection or Mannitol resulted in devation of ADR of Esdn. Conclusion： Low concentration and monotherapy of Esdn can reduce ADR and improve the complianee of the patients,

关 键 词：Β-七叶皂甙钠 局部不良反应 防治 

分 类 号：R97[医药卫生—药品]