2型糖尿病患者颈动脉内膜中层厚度及其相关危险因素分析  

Analysis of Risk Factors about Carotid Intima-media Thickness in Type 2 Diabetes Patients

作　　者：沈娟[1] 唐艰音[1] 郁红[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院内分泌科,上海201900

出　　处：《医学临床研究》2008年第3期432-433,436,共3页Journal of Clinical Research

摘　　要：【目的】探讨2型糖尿病(T2DM)患者颈动脉内膜中层厚度(IMT)的危险因素并进行分析。【方法】超声检测98例T2DM患者颈动脉IMT及粥样斑块形成情况,并予血糖、血脂、血尿酸等生化检查,根据有无粥样斑块形成分为无斑块组与斑块组,并分析各危险因素之间的相关性,进行评估。【结果】T2DM患者中斑块发生率为46.94%,有斑块组糖尿病病程、高血压病程、年龄明显高于无斑块组,比较有显著差异。相关性分析显示IMT与高血压病程、年龄、载脂蛋白B(ApoB)、脂蛋白(a)[Lp(a)]等呈正相关。【结论】T2DM患者颈动脉IMT受多种因素影响,控制血压、脂代谢紊乱有助于延缓动脉粥样硬化发展。[Objective] To investigate risk factors about carotid intima-media thickness（IMT） in Type 2 Diabetes（T2DM） patients. [Methods]Carotid IMT was observed by B-ultrasonography and evaluated by the percentage of plaque in 98 patients with T2DM. Levels of plasma glucose, blood lipids and uric acid biochemical parameters were measured in these patients. The patients were divided into plaque group and non-plaque group. The correlations among risk factors were analyzed. [Results]The plaque incidence in T2DM patients was 46.940%. The diabetes mellitus （DM） history, the hypertensive history and age in patients with plaque were significantly greater than those in patients without plaque. IMT was positively correlated with hypertensive history, age, apolipoproteinB（apoB） and lipoprotein（a） [Lp（a）]. [Conclusion] Carotid IMT in T2DM patients is influenced by various kinds of factors. Controlling blood pressure and fat metabolic disorder will delay the progression of atherosclerosis.

关 键 词：颈动脉/超声检查 糖尿病并发症 危险因素 

分 类 号：R587.2[医药卫生—内分泌]