纳米级支架材料在骨组织工程中的应用  

The application of nanostructured scaffold materials in bone tissue engineering

作　　者：赵君[1] 蒋欣泉[1] 张志愿[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面外科上海市口腔医学研究所,上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2008年第2期137-140,共4页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(30400502);上海市科学技术委员会科研基金(04dz05601;05DJ14006;055407034;05QMX1426);上海市重点学科建设项目(Y0203)~~

摘　　要：骨组织工程研究领域中,支架材料与细胞的相互作用是主要的研究课题。支架材料表面的微观结构对细胞的生物调控作用非常重要。纳米材料因具有一些独特的效应,有利于细胞的黏附、增殖和功能的增强,因而作为骨组织工程支架有着良好的应用前景。目前用于骨组织工程的纳米支架材料主要有纳米复合材料和纳米纤维材料。作者就纳米支架材料与细胞作用的机制以及近年来其在骨组织工程中的应用研究现状作一综述。The study of scaffold material-cell interactions was the major subject in the field of bone tissue engineering. Micro-structured surfaces of materials had more remarkably biological control on cells. Nanostructured scaffold materials have particular effects which could enhance biologic activity,adhesiveness and proliferation of cells. At present, nanocomposite constructs and nanofiber scaffolds are the major materials researched in bone tissue engineering. This review focuses on the mechanism of nanomaterial-cell interactions and the present status of application of nanomaterials in bone tissue engineering. Supported by National Natural Science Foundation of China（Grant No.30400502）, Research Fund of Science and Technology Committee of Shanghai Municipality （Grant No.04dz05601,05DJ14006, 055407034, 05QMX1426） and Shanghai Leading Academic Discipline Project（Grant No.Y0203）.

关 键 词：纳米材料 支架材料 骨组织工程 

分 类 号：R318.0[医药卫生—生物医学工程]