结核性和恶性胸腔积液中白介素-2、白介素-8、肿瘤坏死因子α和干扰素γ的变化  

The changes of Interleukin-2 and interleukin-8 and tumour necrosis factor-α and interferon-γ of tuberculous and malignant pleural effusions

作　　者：张丽君[1] 温学萍[1] 颜志军[1] 

机构地区：[1]上海瑞金医院闵行区中心医院,上海201100

出　　处：《现代中西医结合杂志》2008年第12期1789-1791,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察胸腔积液中白介素-2(IL-2)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)在结核性和恶性胸腔积液中的含量及其对鉴别诊断的价值。方法测定并比较111例结核性、恶性、肺炎性及漏出液4组不同病因胸腔积液患者血清IL-2、IL-8、TNF-α和IFN-γ水平。结果结核性、恶性组患者胸腔积液和血清中的IL-8、TNF-α和IFN-γ水平显著高于漏出液组(P均<0.01);结核性胸腔积液组患者胸液中IL-8、TNF-α和IFN-γ含量明显高于恶性胸腔积液组(P均<0.05);结核性胸腔积液组患者血清中IFN-γ含量明显高于恶性胸腔积液组(P<0.05)。结论胸腔积液中IL-8、TNF-α和IFN-γ联检可能对结核性和恶性胸腔积液之间的鉴别都有较高的临床意义。Objective It is to observe and compare the significance of interleukin- 2 （IL- 2）, interleukin - 8 （IL- 8）, turnout necrosis factor- α （TNF- α）, and interferon - y（ IFN - y） in pleural effusions for the diagnosis of tuberculous and malignant pleural effusions. Methods The effusion and serum levels of IL - 2, IL - 8, TNF - α and IFN - ywere measured in 111 patients with pleural effusion. Results The effusion and serum levels of IL- 8, TNF- aand INF- y in tuberculous and malignant effusion patients were significantly higher than those pleural transudate patients （P 〈 0.01 ）. The levels of IL- 8, TNF- aand IFN-y in pleural effusion of tuberculous effusion were obviously higher than those with malignant effusion （P〈 0.05）. The serum level of IFN- y in tuberculosis pleural effusion was obviously higher than those with malignant effusion （ P〈 0.05 ）. Conclusion The determination of IL - 8, TNF - α and IFN - y levels in pleural effusions may be beneficial to identification of tuberculous and malignant effusions.

关 键 词：胸腔积液 白介素-2 白介素-8 肿瘤坏死因子Α 干扰素-Γ 

分 类 号：R521[医药卫生—内科学] R73[医药卫生—临床医学]