71例狼疮性肾炎的病理与临床分析  

Pathological category and clinical characteristics of lupus nephritis (A report of 71 cases)

作　　者：游运辉[1] 左晓霞[1] 尹红玲[2] 罗卉[1] 赵洪军[1] 刘萍[1] 

机构地区：[1]中南大学湘雅医院风湿免疫科,湖南长沙410008 [2]中南大学基础医学院病理教科室,湖南长沙410008

出　　处：《中国现代医学杂志》2008年第5期626-627,630,共3页China Journal of Modern Medicine

摘　　要：目的探讨狼疮性肾炎(LN)的病理与临床特点,了解病理改变与临床表现之间的联系。方法回顾性分析71例LN病人的病理类型与临床特征。结果Ⅱa、Ⅱb、Ⅲ、Ⅳ、Ⅴ、Ⅵ型各占14%、25%、17%、30%、5%、9%;Ⅱb、Ⅳ型血尿发生率较高,Ⅳ、Ⅴ型肾病综合征(肾综)发生率较高,高血压、肾功能不全发生率在Ⅳ型最高,与其他组比较,差异均有显著性;所有病例肾脏病理均有活动性病变,但其中有21%病人血清补体及SLEDAI评分正常。结论LN中血尿多出现在以增生性病变为特征的Ⅱ、Ⅳ型;表现为肾综、高血压及肾功能不全的以Ⅳ型居多;对于部分血清补体正常、SLEDAI评分正常的病人肾脏病理仍可能有活动性病变。[Objective] To analyze the pathological category and the clinical characteristics of Lupus nephritis retrospectively. [Method] The pathological category and clinical characteristics of lupus nephritis. [Result] Among 71 cases, all patients were suffered from activitive kidney involvement： with type Ⅱa, Ⅱb, Ⅲ, Ⅳ, Ⅴ, Ⅵ accounting for 14%, 25%, 17%, 30%, 5% and 9%. Incidence rate of hematuria was significantly higher than that in type Ⅱb Ⅳ, incidence rate of nephrotic syndrome was significantly higher than that in type ⅣⅤ, incidence rate of hypertension and renal function failure was significantly higher in type Ⅳ than others. Serum complement and SLEDAI were normal in 21﹪ patients. [Conclusion] Hematuria always occur in type Ⅱ Ⅳ. Nephrotic syndrome hypertension and renal function failure always occur in type Ⅳ. These patients whose serum complement and SLEDAI were normal present possiblely activitive kidney involvement.

关 键 词：红斑狼疮 狼疮性肾炎 肾病综合征 高血压 病理学 

分 类 号：R593.242[医药卫生—内科学]