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作 者:黄育丹[1] 瞿尔力[1] 邓秀睿[1] 陈清[1] 苏卫东[1]
机构地区:[1]温州市第二人民医院新生儿科,浙江温州325000
出 处:《实用儿科临床杂志》2008年第6期444-445,共2页Journal of Applied Clinical Pediatrics
摘 要:目的探讨氧交换指标对新生儿呼吸窘迫综合征(NRDS)诊断及治疗价值。方法选取2003年1月-2006年12月在新生儿重症监护室中应用呼吸机治疗的30例NRDS患儿(NRDS组),以及同期住院治疗的23例新生儿肺炎并急性呼吸衰竭的新生儿(对照组)为研究对象。监测二组患儿在机械通气早期(上机2h内)、中期(上机48~72h)及撤机前(撤机前0.5—2.0h)肺泡.动脉血氧分压差(A-aDO2)、呼吸指数(R1)、氧合指数(0I)、动脉血氧分压[Pa(O2)]、Pa(O2)和PA(O2)的变化。应用SPSS10.0软件进行统计学分析。结果二组患儿在机械通气的早期RI、OI、A-aDO2比较差异有统计学意义(Pa〈0.001),Pa(O2)/Pa(O2)比较差异有统计学意义(P〈0.05),Pa(O2)比较差异无统计学意义(P〉0.05);二组患儿在机械通气的中期RI、A—aDO2比较差异有统计学意义(Pa〈0.001),OI、Pa(O2)/pA(O2)比较差异有统计学意义(Pa〈0.05),Pa(O2)比较差异无统计学意义(P〉0.05);在撤离呼吸机前二组患儿各项指标比较差异均无统计学意义(Pa〉0.05)。结论A-aDO2、RI、OI,pa(O2)/pA(O2)可作为NRDS早期诊断、观察及指导撤机的指标。Objective To explore the clinical value of diagnosis and treatment of oxygen exchange in neonatal respiratory distress syndrome (NRDS). Methods Thirty neonates with NRDS were selected as treatment group in neonatal intensive care unit (NICU) from Jan. 2003 to Dec. 2006, and 23 neonates .with infectious pneumonia complicating acute respiratory failure in NICU at the same time were as control group. The changes of respiratory index (RI), oxygenation index (IO), A - aDO2 ,pa ( O2 )/PA ( O2 ) ,Pa( O2 ) in 2 groups were observed in the early period( mechanical ventilation 0 -2 h), the middle period( mechanical ventilation 48 -72 h)and before ventilation weaning(0.5 -2.0 h before ventilation weaning). Results In the early periods, there were significant differences in RI, OI,p, ( 02 )/PA ( O2 ) and A - aDO2 between 2 groups ( P. 〈 0.05 ), but there was no significant difference in pa( O2 ) between 2 groups ( P 〉 0.05 ). In the middle periods, there were significant differences in RI, OI ,pa ( O2 )/pA ( O2 ) and A - aDO2 between 2 groups ( Pa 〈 0.05 ) , but there was no significant difference in p. (02 ) between 2 groups( P 〉 0.05 ). Before ventilation weaning, there was no significant difference in all criteria between 2 groups( Pa〉 0.05 ). Conclusion Indexes of oxygen function may become criteria of early diagnosing NRDS,observing effect of treatment and guidance of ventilation weaning.
关 键 词:氧交换指标 新生儿呼吸窘迫综合征 急性呼吸衰竭
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