N-[5-(3-吡啶基)-1，3，4-噻二唑-2-基]-N′-取代苯基脲的合成及生物活性  

Synthesis and biological activity of N-[5-(3-pyridyl)-1,3,4-thiadiazol-2-yl]-N′-(substituted phenyl)ureas

作　　者：谭小红[1] 宋新建[1] 汪焱钢[2] 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000 [2]华中师范大学化学学院,武汉430079

出　　处：《华中师范大学学报（自然科学版）》2008年第1期62-64,共3页Journal of Central China Normal University：Natural Sciences

基　　金：湖北省自然科学基金资助项目(2007ABA001);湖北省教育厅优秀中青年人才项目(Q200729001)

摘　　要：为了寻找高生物活性的脲类化合物,通过2-氨基-5-(3-吡啶基)-1,3,4-噻二唑与酰基叠氮化物反应,设计合成了7个新的N-[5-(3-吡啶基)-1,3,4-噻二唑-2-基]-N'-取代苯基脲,其中芳酰基叠氮化物是以芳酸、氯甲酸乙酯、叠氮化钠为起始原料采用"一锅法"所制得.目标化合物的结构经红外光谱、核磁共振氢谱和元素分析予以确证.初步的生物活性测定表明,部分目标化合物具有良好的植物生长调节活性.In order to find biologically active urea compounds, seven new N-[5-（3 pyridyl）-l, 3,4-thiadiazol 2-yl] N-（substituted phenyl）urea derivatives were synthesized by the reaction of 2-amino 5 （3 pyridyl）-l, 3,4 thiadiazole with aroylazides, which were prepared starting from carboxylic acids, ethyl chloroformate and sodium azide by one-pot procedure. Their structures were confirmed by IR, 1H NMR spectroscopy and elementary analysis. The preliminary bio- logical activity tests showed that some of the title compounds have good plant growth regulating activity.

关 键 词：噻二唑 脲 合成 植物牛长调节活性 

分 类 号：O621.29[理学—有机化学]