索拉非尼的合成工艺改进  

To improve synthesis technology of Sorafenib

作　　者：吴思晋[1] 张晓蕾[2] 沈义鹏[3] 张爱华[3] 

机构地区：[1]南京工业大学制药与生物科学学院材料化学工程国家重点实验室,江苏南京210009 [2]南京中医药大学,江苏南京210046 [3]江苏省药物研究所有限公司,江苏南京210000

出　　处：《齐鲁药事》2008年第3期168-170,共3页qilu pharmaceutical affairs

摘　　要：目的合成一种新型的多激酶抑制剂。方法以吡啶甲酸为原料,经过氯化,酰胺化,缩和并成盐制备获得对甲基苯磺酸索拉非尼。结果及结论改进后的工艺合成收率高,化合物经过元素分析,质谱,氢谱和红外光谱确证,产品纯度高。OBJECTIVE To synthesis a new type multi kinase inhibitor. METHODS 2-pieolinie acid was used as start material, through chlorination, amidation, condensation sorafenib tosylate were sythesed. RESULTS and CONCLUSION Srafenib tosylate was synthesed in high yield. The structure of the target compound was comfirmed by element analysis, MS, H -NMR and IR. The purity of the final product was high.

关 键 词：索拉非尼 抗肿瘤药物 合成 多激酶抑制剂 

分 类 号：TQ460.6[化学工程—制药化工]