酮洛芬印迹聚合物的合成及性能研究  

Synthesis and evaluation of molecularly imprinted polymers using α-(3-benzoylphenyl) propionic acid as template

作　　者：邵园[1] 刘照胜[1] 郝兰芳[1] 段宏泉[1] 

机构地区：[1]天津医科大学药学院天然药物化学教研室,天津300070

出　　处：《天津医科大学学报》2008年第1期5-8,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(20575045)

摘　　要：目的:探讨采用分子印迹技术制成的分子印迹聚合物对酮洛芬的特异性吸附作用。分析比较模板分子与功能单体之间的作用,同时对以不同功能单体合成的聚合物的结合性能进行研究。方法:以酮洛芬为模板分子,乙二醇二甲基丙烯酸酯为交联剂,分别以丙烯酰胺、甲基丙烯酸和加入甲基丙烯酸丁酯的甲基丙烯酸为功能单体,合成了对酮洛芬具有特异性吸附能力的3种分子印迹聚合物。结果:用丙烯酰胺合成的分子印迹聚合物对模板分子酮洛芬的结合能力最强。其中以丙烯酰胺和甲基丙烯酸为功能单体制成的聚合物对酮洛芬都存在两类不同亲和性的结合位点,而以混合功能单体制成的聚合物对酮洛芬存在一类亲和性结合位点。结论:该方法条件简单方便,对分子印迹技术用于环境、血液等复杂样品中酮洛芬的分离和富集具有重要意义。Objective： To study the molecular imprinted polymers（MIPs） which have a specific molecule recognition ability to α-（3-benzoylphenyl） propionic acid （BPA） by molecular imprinting technique（MIT）, investigate the interaction between the template molecule and the functional monomer,and explore the adsorption effect of three kinds of polymers with different functional monomers. Methods： In the procedure, MIPs were synthesized taking BPA as template, 2,2＇-azobisisobutyronitrile （AIBN） as initiator and ethylene glycol dimethacrylate （EDMA） as cross-linker by molecular imprinting technology.Acrylamide （AM）,α- methylacrylic acid （MAA）,mixture of MAA and butyl methacrylate （BMA） were selected as functional monomer. Results： The interaction between the BPA and AM was the strongest in the three kinds of polymers.There were two sorts of bingding-site in the polymers which used AM and MAA as functional monomer,however,there was only one bingding-site in the polymers that used mixture of MAA and BMA as functional monomer. Conclusion： The method is simple and convient,meanwhile,it is significant in the application of MIT in the separation and enrichment of BPA in complex samples, such as blood.

关 键 词：分子印迹技术 分子印迹聚合物 酮洛芬 功能单体 

分 类 号：TQ[化学工程]