寻常性银屑病患者血浆内毒素及药物干预研究  

Determination of the Plasma Level of Endotoxin in Patients with Psoriasis Vulgaris

作　　者：韩静倩[1] 徐丽敏[1] 

机构地区：[1]天津市长征医院,天津300120

出　　处：《中国中西医结合皮肤性病学杂志》2008年第1期13-15,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨寻常性银屑病患者血浆中内毒素水平和药物治疗后的变化。方法采用酶联免疫吸附试验检测银屑病患者药物治疗前后和正常人血浆中内毒素水平。结果患者组血浆中内毒素较正常对照组升高,有统计学意义;患者组经治疗皮损明显消退后,血浆内毒素水平也下降,治疗前后比较有统计学意义。结论革兰氏阴性细菌感染所产生的内毒素可能与银屑病发病存在相关性。Objective To investigate the plasma level of endotoxin in patients with psoriasis vulgaris, Methods The plasma levels of endotoxin in patients and normal controls were tested by enzyme-linked imuunosorbent assay （ELISA）. Resuits Compared with that in healthy controls, the plasma endotoxin level in patients with psiriasis vulgaris was significantly increased（P〈0.05）, The endotoxin level in patients who recovered completely was significantly decreased after the treatment （P〈0.05）, Conclusion There is a relationship between gram negative bacteria infection and the pathogenesis of psoriasis,

关 键 词：内毒素 银屑病 酶联免疫吸附试验 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]