环丙沙星(CPFX)—锌(Ⅱ)的络合性能及环丙沙星的含量测定  

Complexation Characteristics of Ciprofloxacin with Zn(Ⅱ) and Determination of Ciprofloxacin

作　　者：王爱芳[1] 董学芝[1] 张国胜[1] 李畅[1] 

机构地区：[1]河南大学化学化工学院污控研究所,开封475004

出　　处：《黑龙江医药》2008年第2期3-5,共3页Heilongjiang Medicine journal

摘　　要：目的:研究环丙沙星(CPFX)-锌(Ⅱ)络合物的配比、离解度和稳定常数,并建立简单、快速、灵敏的测定环丙沙星的络合紫外分光光度法。方法:采用紫外分光光度法,检测波长λ=277nm。结果:线性范围0.4～16 mg·L^(-1),线性回归方程为 A=0.10356c(mg·L^(-1))+0.00275,相关系数 R=0.9999,最低检出限为0.0117 mg·L^(-1)。结论:此法用于环丙沙星药物的测定,结果令人满意。Objective： To study the complexation characteristics of ciprofloxacin（CPFX） with Zn（ Ⅱ ）, including the complexing tatio, the degree of dissociation and stability constant, and to establish a complexing UV method for the determination of ciprofloxacin. Methods： The UV pectrophotcmetry was used. The detecting wavelength was at 277nm. Results：The linear range is 0.4-16 mg·L^-1 and the regression equation is A= 0.10356c（mg · L^-1） ＋ 0.00275 （R= 0.9999） with the detection limit of 0.0117 mg· L^-1. Conclusion： The method was applied to the determination of ciprofloxacin drugs with good results.

关 键 词：环丙沙星 锌 络合 紫外 

分 类 号：R927.2[医药卫生—药学]