强直性脊柱炎患者血清白介素1β、2、6及肿瘤坏死因子-α测定的意义  

The significance of serum interleukin-1β, interleukin-2, interleukin-6 and TNF-α levels in patients with ankylosing spondylitis

作　　者：叶俏[1] 杜瑛媛[1] 顾旭东[1] 王宙政[1] 沈洁[1] 倪桂珍[1] 

机构地区：[1]浙江省嘉兴市第二医院风湿免疫科,嘉兴314000

出　　处：《中华物理医学与康复杂志》2008年第3期162-164,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的观察强直性脊柱炎（AS）患者外周血清白介素-1β（IL-1β）、白介素-2（IL-2）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、红细胞沉降率（ESR）、C反应蛋白（CRP）、免疫球蛋白（IgA、IgG、IgM）水平，并分析它们与强直性脊柱炎疾病活动指数（BASDAI）相关性。方法测定45例AS患者及30例健康体检者的IL-1β、2、6及TNF-α，CRP、IgA、IgG、IgM、ESR水平。以Bath强直性脊柱炎疾病活动指数（BASDAI）评定AS患者疾病活动性，取BASDAI中位数将患者分为活动组及非活动组，比较AS患者与对照组，活动组与非活动组各实验指标，分析它们与BASDAI的相关性。结果AS患者ESR、CRP、IgA、IgM、IgG、IL-1β、IL-2、IL-6及TNF-α水平与对照组之间差异有统计学意义（P〈0．05）。AS患者活动组CRP、IL-2与IL．6较非活动组差异有统计学意义（P〈0．05）。AS患者CRP与IL-6，IL-2与IL-6，IgA与IgG两两之间成正相关，但只有IL-2、IL-6及CRP与BASDAI之间成正相关。结论IL-2、IL-6与CRP可作为AS疾病活动性的参考指标。Objective To investigate the significance of serum interleukin-1β, interleukin-2, interleukin- 6, TNF-α, erythrocyte sedimentation rate （ESR）, c-reactive protein （CRP）, IgA, IgG and IgM in patients with ankylosing spondylitis （AS） , and to analyze their relationship with the Bath ankylosing spondylitis disease activity index （ BASDAI）. Methods Participants of this study included 45 AS patients （ patient group） and 30 healthy subjects （ control group）. The patient group was further divided into an active subgroup and an inactive subgroup based on the disease activity assessed by using BASDAI. Then serum levels of IL-1β, IL-2, IL-6, TNF-α, ESR, CRP, IgA, IgG and IgM were tested in all the subjects, and the values were compared between different groups. In addition, the relationship between various parameters and those with BASDAI were also evaluated. Results The serum levels of ESR, CRP, IgA, IgM, IgG, IL-1β, IL-2, IL-6 and TNF-α in patients with AS were significantly higher than those in the healthy controls （P 〈 0.05）. The serum level of CRP, IL-2 and IL-6 were significantly different between the active and inactive subgroups （P 〈 0.05 ）. There was a positive correlation between CRP and IL-6, IL-6 and IL-2, as well as IgA and IgG levels. The IL-2, IL-6 and CRP levels were positive correlated with BASDAI. Conclusion It was suggested that the serum levels of IL-2, IL-6 and CRP can be used to assess the disease activity in patients with AS.

关 键 词：强直性脊柱炎 白介素1Β 白介素2 白介素6 肿瘤坏死因子-Α 

分 类 号：R593.23[医药卫生—内科学] R587.1[医药卫生—临床医学]